Taurine 7 pp 105-112 | Cite as

Mechanism of TauT in Protecting Against Cisplatin-Induced Kidney Injury (AKI)

  • Xiaobin Han
  • Russell W. Chesney
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 643)


Acute renal failure (ARF) results from ischemic or toxic renal injury and is a common disorder with an overall mortality rate of about 50%. Despite the advent of dialysis and increasing knowledge regarding the causes and the effects of ARF, this trend has hardly changed for several decades. Cisplatin is a broadly used anticancer drug and is widely known to induce acute renal failure as a result of renal tubular injury. In this study, we have demonstrated that: (1) TauT is down-regulated by the p53 tumor suppressor gene in renal proximal tubule LLC-PK1 cells; (2) cisplatin down-regulates the expression of TauT in renal proximal tubule cells through, at least in part, a p53-dependent pathway; and (3) forced overexpression of TauT can attenuate cisplatin-induced apoptosis of renal proximal tubule cells.


Acute Renal Failure Taurine Transporter Taurine Uptake Renal Tubular Injury Relative Light Output 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Xiaobin Han
    • 1
  • Russell W. Chesney
  1. 1.Department of PediatricsUniversity of Tennessee Health Science Center and the Children’s Foundation Research Center at Le Bonheur Children’s Medical CenterMemphisUSA

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