Abstract
Acute renal failure (ARF) results from ischemic or toxic renal injury and is a common disorder with an overall mortality rate of about 50%. Despite the advent of dialysis and increasing knowledge regarding the causes and the effects of ARF, this trend has hardly changed for several decades. Cisplatin is a broadly used anticancer drug and is widely known to induce acute renal failure as a result of renal tubular injury. In this study, we have demonstrated that: (1) TauT is down-regulated by the p53 tumor suppressor gene in renal proximal tubule LLC-PK1 cells; (2) cisplatin down-regulates the expression of TauT in renal proximal tubule cells through, at least in part, a p53-dependent pathway; and (3) forced overexpression of TauT can attenuate cisplatin-induced apoptosis of renal proximal tubule cells.
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References
Godley LA, Eckhaus M, Paglino JJ, Owens J, Varmus HE (1996) Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys. Genes Dev 10: 836–850
Gurujeyalakshmi G, Wang Y, Giri SN (2000) Suppression of bleomycin-induced nitric oxide production in mice by taurine and niacin. Nitric Oxide 4:399–411
Han X, Budreau AM, Chesney RW (2000) The taurine transporter gene and its role in renal development. Amino Acids 19:499–507
Han X, Budreau AM, Chesney RW (2002) Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells. J Biol Chem 277:39266–39273
Han X, Chesney RW (2006) Regulation of TauT by cisplatin in LLC-PK1 renal cells. Pediatr Nephrol 20:1067–1072
Huang XM, Zhu WH, Kang ML (2003) Study on the effect of doxorubicin on expressions of genes encoding myocardial sarcoplasmic reticulum Ca2+ transport proteins and the effect of taurine on myocardial protection in rabbits. J Zhejiang Univ Sci 4:114–120
Jiang M, Yi X, Hsu S, Wang CY, Dong Z (2004) Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity. Am J Physiol Renal Physiol 287:F1140–F1147
Maar TE, Lund TM, Gegelashvili G, Hartmann-Petersen R, Moran J, Pasantes-Morales H, Berezin V, Bock E, Schousboe A (1998) Effects of taurine depletion on cell migration and NCAM expression in cultures of dissociated mouse cerebellum and N2A cells. Amino Acids 15:77–88
Miyaji T, Kato A, Yasuda H, Fujigaki Y, Hishida A (2001) Role of the increase in p21 in cisplatin-induced acute renal failure in rats. J Am Soc Nephrol 12:900–908
Park MS, De Leon M, Devarajan P (2002) Cisplatin induces apoptosis in LLC-PK1 cells via activation of mitochondrial pathways. J Am Soc Nephrol 13(4):858–65
Seabra V, Stachlewita RF, Thurman RG (1998) Taurine blunts LPS-induced increases in intracellular calcium and TNF-alpha production by Kupffer cells. J Leukoc Biol 64:615–621
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Han, X., Chesney, R.W. (2009). Mechanism of TauT in Protecting Against Cisplatin-Induced Kidney Injury (AKI). In: Azuma, J., Schaffer, S.W., Ito, T. (eds) Taurine 7. Advances in Experimental Medicine and Biology, vol 643. Springer, New York, NY. https://doi.org/10.1007/978-0-387-75681-3_11
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DOI: https://doi.org/10.1007/978-0-387-75681-3_11
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-75680-6
Online ISBN: 978-0-387-75681-3
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