Diagnostic Imaging and Image-Guided Interventions of Hepatobiliary Malignancies

  • Unni Udayasankar
  • Abbas Chamsuddin
  • Pardeep Mittal
  • William C. Small
Part of the Cancer Treatment and Research book series (CTAR, volume 143)

The unique histological characteristics, combined with a high vascularity and biochemical load, increase the vulnerability of hepatic tissue for the development of primary and metastatic tumors. The number of cases of hepatocellular carcinoma (HCC) has increased over the past two decades [1], and approximately 10,000 people are estimated to die annually from primary hepatic and biliary cancers in the United States [2]. Hepatic metastases contribute to mortality in a large number of patients. Recent advances in imaging techniques, including molecular and cellular biology, assist in early diagnosis, treatment and follow-up of hepatobiliary tumors [3-7]. Imaging plays an important role, since the diagnosis and management of many liver tumors has witnessed a sharp change in the last two decades. Imaging modalities such as ultrasound and computerized tomography (CT) are frequently used for staging cancer patients for hepatic metastatic tumor spread, and for evaluating patients with preexisting liver disease (chronic hepatitis or cirrhosis) to look for development of potential primary malignancies. Contrast-enhanced CT, magnetic resonance imaging (MRI) or molecular imaging techniques, including positron emission tomography (PET), are used to estimate the tumor burden, vascular or biliary invasion and residual normal liver volume. Imaging also facilitates diagnosis and treatment by guided procedures including percutaneous biopsy, radiofrequency ablation (RFA) and transarterial chemoembolisation (TACE).


Arterial Phase Gallbladder Carcinoma Helical Computerize Tomography Focal Nodular Hyperplasia Portal Venous Phase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Unni Udayasankar
    • 1
  • Abbas Chamsuddin
    • 1
  • Pardeep Mittal
    • 1
  • William C. Small
    • 1
  1. 1.Emory University School of MedicineAtlantaUSA

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