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Peripheral Nociceptors

  • Chapter
Molecular Pain

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Abstract

Noxious stimuli extite primary afferent sensory neurons through activation of various ionotropic receptors expressed in the nerve endings, followed by action potential generation upon activation of voltage-gated Na+ channels. Nociceptive cation channels include TRP channels, P2X receptors and acid-sensing ion channels (ASICs). On the other hand, opening of K+ channels causes hyperpolarization, leading to reduction in nociception. Both activity and expression of nociceptive cation channels, voltage-gated Na+ channels and K+channels are affected by many kinds of factors including inflammatory mediators. Thus, excitability of nociceptive neurons is regulated by dynamic balance in activities of those molecules, and clarification of molecular mechanisms in peripheral nociception would be useful for the development of novel analgesic agents.

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  1. Section Cell Signaling, Okazaki Institute of Integrative Bioscience, Higashiyama 5-1 Myodaiji, Okazaki, 444-8787, Japan

    Makoto Tominaga MD, PhD (Professor)

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  1. Makoto Tominaga MD, PhD
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  1. Department of Physiology, University of Toronto, Medical Sciences Bldg, Rm 3342 1 King’s College Circle, Toronto, Ontario, Canada, M5S 1A8

    Min Zhuo

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© 2007 Higher Education Press

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Tominaga, M. (2007). Peripheral Nociceptors. In: Zhuo, M. (eds) Molecular Pain. Springer, New York, NY. https://doi.org/10.1007/978-0-387-75269-3_19

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  • DOI: https://doi.org/10.1007/978-0-387-75269-3_19

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-75268-6

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