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Molecular Pain pp 145–154Cite as

Retrograde Messengers

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Abstract

In the neuronal circuit, feedback control is an important mechanism to maintain the stability of the circuit. Among many different signaling molecules, diffusible, gaseous messengers such as nitric oxide (NO) and carbon monoxide (CO) serve as key retrograde messengers in central excitatory synapses. Due to its rapid synthesis and non-vesicle dependent release, these gaseous messengers play different roles in synaptic transmission, in particular the plasticity. In this chapter, we will use NO and CO as two major examples of retrograde messenger families to explore their roles in central plasticity. We will discuss the synthesis of NO and CO, molecular target and downstream signaling proteins for NO and CO. Finally, we will also review the physiological functions of NO and CO in learning & memory, sensory transmission and pain, and cortical functions.

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Authors and Affiliations

  1. Department of Physiology, University of Toronto, Medical Sciences Bldg, Rm 3342, 1 King’s College Circle, Toronto, Ontario, M5S 1A8, Canada

    Min Zhuo PhD (Canada Research Chair in Pain and Cognition, Tier I EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health, Professor)

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  1. Min Zhuo PhD
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Editors and Affiliations

  1. Department of Physiology, University of Toronto, Medical Sciences Bldg, Rm 3342 1 King’s College Circle, Toronto, Ontario, Canada, M5S 1A8

    Min Zhuo

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© 2007 Higher Education Press

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Zhuo, M. (2007). Retrograde Messengers. In: Zhuo, M. (eds) Molecular Pain. Springer, New York, NY. https://doi.org/10.1007/978-0-387-75269-3_12

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  • DOI: https://doi.org/10.1007/978-0-387-75269-3_12

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-75268-6

  • Online ISBN: 978-0-387-75269-3

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