Hypercalcemic Crisis

  • Theresa W. Ruddy

Hypercalcemia is rare in hospitalized patients, occurring at a reported rate of less than 1% of patients in this country. Hypercalcemia is the result of excessive skeletal calcium release, increased intestinal calcium absorption, or inadequate excretion of calcium. The two most common conditions that account for 90% of patients with hypercalcemia are primary hyperparathyroidism and cancer. Malignancies such as multiple myeloma, lymphoma, and metastatic breast cancer can invade bone and cause direct bone reabsorption leading to hypercalcemia. Other malignancies can release parathyroid hormone-like substances that cause hypercalcemia. Rarer causes of hypercalcemia include use of thiazide diuretics, lithium therapy, excessive vitamin D intake, immobilization, hyperthyroidism, and complicated renal failure.


Multiple Myeloma Metastatic Breast Cancer Primary Hyperparathyroidism Parathyroid Adenoma Serum Calcium Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Theresa W. Ruddy
    • 1
  1. 1.Department of Colon and Rectal SurgeryBrown University, Rhode Island HospitalProvidenceUSA

Personalised recommendations