Cancer of the perianal skin (anal margin) and anal canal are uncommon malignancies, constituting less than 5% of cancers of the lower gastrointestinal tract. Most cancers in this region arise cephalad to the dentate line of the anal canal by a ratio of 3 to 1. Anal canal cancers are more frequently found in women, and anal margin tumors are more frequently found in men. Regardless of location, the patients are usually in their mid-50s when the diagnosis is established.
KeywordsHuman Papilloma Virus Local Excision Dentate Line Human Papilloma Virus Infection Combine Modality Therapy
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