Transfusion Reactions

  • Jennifer B. Manders

Despite advances that have been made in collection, distribution, and safety of blood and blood products, serious complications can arise from their transfusion. After a massive transfusion (a single transfusion of 2,500–5,000ml over 24h), a variety of problems can occur. These include circulatory overload, DIC, dilutional thrombocytopenia, impaired platelet function, hypothermia-induced coagulopathy due to cold products, deficiency of factors V, VII, XI, and hyperkalemia.

The use of blood from several donors increases the likelihood of a hemolytic reaction due to incompatibility. The incidence of nonfatal hemolytic reactions is approximately 1 in 6,000 units of blood administered. Fatal hemolytic reactions occur in 1 out of 100,000 units administered.


Trypanosoma Cruzi Massive Transfusion Yersinia Enterocolitica Transfusion Reaction Hemolytic Reaction 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Jennifer B. Manders
    • 1
  1. 1.Cincinnati Onco-Plastic SurgeryCincinnatiUSA

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