Despite advances that have been made in collection, distribution, and safety of blood and blood products, serious complications can arise from their transfusion. After a massive transfusion (a single transfusion of 2,500–5,000ml over 24h), a variety of problems can occur. These include circulatory overload, DIC, dilutional thrombocytopenia, impaired platelet function, hypothermia-induced coagulopathy due to cold products, deficiency of factors V, VII, XI, and hyperkalemia.
The use of blood from several donors increases the likelihood of a hemolytic reaction due to incompatibility. The incidence of nonfatal hemolytic reactions is approximately 1 in 6,000 units of blood administered. Fatal hemolytic reactions occur in 1 out of 100,000 units administered.
KeywordsTrypanosoma Cruzi Massive Transfusion Yersinia Enterocolitica Transfusion Reaction Hemolytic Reaction
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