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Transfusion Reactions

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Common Surgical Diseases

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Despite advances that have been made in collection, distribution, and safety of blood and blood products, serious complications can arise from their transfusion. After a massive transfusion (a single transfusion of 2,500–5,000ml over 24h), a variety of problems can occur. These include circulatory overload, DIC, dilutional thrombocytopenia, impaired platelet function, hypothermia-induced coagulopathy due to cold products, deficiency of factors V, VII, XI, and hyperkalemia.

The use of blood from several donors increases the likelihood of a hemolytic reaction due to incompatibility. The incidence of nonfatal hemolytic reactions is approximately 1 in 6,000 units of blood administered. Fatal hemolytic reactions occur in 1 out of 100,000 units administered.

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Authors and Affiliations

  1. Cincinnati Onco-Plastic Surgery, Cincinnati, OH, 45219-0772, USA

    Jennifer B. Manders (Breast Surgeon)

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  1. Jennifer B. Manders
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Editors and Affiliations

  1. Undergraduate Surgical Education, Rush Medical College of Rush University Rush University Medical Center, Chicago, IL, 60612, USA

    Jonathan A. Myers MD (Assistant Professor of Surgery Director) (Assistant Professor of Surgery Director)

  2. Surgical Sciences and Services, Rush Medical College of Rush University Rush University Medical Center, Chicago, IL, 60612, USA

    Keith W. Millikan MD (Professor of Surgery Associate Dean) (Professor of Surgery Associate Dean)

  3. Section of Colon and Rectal Surgery, Rush Medical College of Rush University Rush University Medical Center, Chicago, IL, 60612, USA

    Theodore J. Saclarides MD (Professor of Surgery Head) (Professor of Surgery Head)

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© 2008 Springer Science+Business Media, LLC

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Manders, J.B. (2008). Transfusion Reactions. In: Myers, J.A., Millikan, K.W., Saclarides, T.J. (eds) Common Surgical Diseases. Springer, New York, NY. https://doi.org/10.1007/978-0-387-75246-4_4

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  • DOI: https://doi.org/10.1007/978-0-387-75246-4_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-75245-7

  • Online ISBN: 978-0-387-75246-4

  • eBook Packages: MedicineMedicine (R0)

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