Chronic ulcerative colitis (CUC) is an inflammatory condition of the colon which begins in the rectum and extends proximally for variable distances. Typical clinical presentation is diarrhea, accompanied by blood and mucus. Patients often have abdominal cramps, urgency, and tenesmus associated with their bowel movements. Patients’ symptoms vary based on the severity of the disease. Physical exam findings may include fever, tachycardia, dehydration, malnutrition, abdominal tenderness, and blood on digital rectal examination. Extracolonic manifestations include arthritis, iritis, oral ulcerations, primary sclerosing cholangitis, and skin conditions such as pyoderma gangrenosum and erythema nodosum. The cause of ulcerative colitis is unknown, is probably multi-factorial, and may include autoimmune phenomena, environmental factors, and genetic predisposition. A family history of inflammatory bowel disease is often usually present.
KeywordsUlcerative Colitis Primary Sclerosing Cholangitis Ileal Pouch Anal Anastomosis Pyoderma Gangrenosum Restorative Proctocolectomy
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