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Zollinger Ellison Syndrome

  • Anthony W. Kim
  • Harry M. RichterIII

Zollinger Ellison syndrome (ZES) is classically characterized by the presence of hypergastrinemia secondary to a gastrinsecreting tumor otherwise known as a gastrinoma. ZES occurs sporadically in 75% of the cases and is associated with multiple endocrine neoplasia-1 (MEN-1) in 25% of cases identified. ZES usually occurs after the onset of hyperparathyroidism in MEN-1 and occurs 50% of the time. Rare causes of hypergastrinemia with acid hypersecretion include retained gastric antrum syndrome, chronic gastric outlet obstruction, chronic renal failure, massive small bowel resection, and gastric G-cell hyperplasia. A careful history and physical, along with other ancillary tests, will help discern these causes from ZES.

Keywords

Serum Gastrin Gastrin Level Zollinger Ellison Syndrome Secretory Diarrhea Gastric Acid Output 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Anthony W. Kim
    • 1
  • Harry M. RichterIII
    • 2
  1. 1.Department of Cardiothoracic SurgeryRush Medical College of Rush University, Rush University Medical CenterChicagoUSA
  2. 2.Department of SurgeryJohn H. Stroger Hospital of Cook CountyChicagoUSA

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