Zollinger Ellison Syndrome

  • Anthony W. Kim
  • Harry M. RichterIII

Zollinger Ellison syndrome (ZES) is classically characterized by the presence of hypergastrinemia secondary to a gastrinsecreting tumor otherwise known as a gastrinoma. ZES occurs sporadically in 75% of the cases and is associated with multiple endocrine neoplasia-1 (MEN-1) in 25% of cases identified. ZES usually occurs after the onset of hyperparathyroidism in MEN-1 and occurs 50% of the time. Rare causes of hypergastrinemia with acid hypersecretion include retained gastric antrum syndrome, chronic gastric outlet obstruction, chronic renal failure, massive small bowel resection, and gastric G-cell hyperplasia. A careful history and physical, along with other ancillary tests, will help discern these causes from ZES.


Serum Gastrin Gastrin Level Zollinger Ellison Syndrome Secretory Diarrhea Gastric Acid Output 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Anthony W. Kim
    • 1
  • Harry M. RichterIII
    • 2
  1. 1.Department of Cardiothoracic SurgeryRush Medical College of Rush University, Rush University Medical CenterChicagoUSA
  2. 2.Department of SurgeryJohn H. Stroger Hospital of Cook CountyChicagoUSA

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