Preoperative Chemo- and Endocrine Therapy

  • Rosalba Torrisi
Part of the Cancer Treatment and Research book series (CTAR, volume 151)

Primary systemic therapy (PST) or preoperative therapy has been part of the multidisciplinary approach to locally advanced and inflammatory breast cancer since the early 1970s. The administration of chemotherapy allowed surgical resection of inoperable tumours and improved clinical outcome [1]. The chance of downsizing the tumour extended its use to operable large breast tumour candidates for mastectomy in order to reduce the extent of surgery. A series of phase II trials reporting an objective response rate ranging from 60 to 90%, showed the feasibility of this approach in terms of significant activity with no detriment to survival [2]. In addition, the early administration of medical treatment appeared an attractive means to improve clinical outcome.


Inflammatory Breast Cancer Hormone Receptor Status HER2 Positive Breast Cancer Recurrence Score Clinical Response Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Research Unit of Medical Senology, Department of MedicineEuropean Institute of OncologyMilanItaly

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