When the media report the results from studies reporting the latest breakthrough in adjuvant drug treatments, they are usually described in terms of relative rather than absolute benefits. Many women with early stage breast (EBC) cancer may not realise that they do not necessarily require any further adjuvant treatments and that claims for example of a 50% reduction in risk of recurrence does not relate to an individual woman’s risk. For many who receive systemic therapy the relative benefits may be small and not outweigh the associated costs of side effects. Until basic science can provide us with a better understanding of how to target treatments to those most likely to derive benefit, we need to collect side-effect data systematically and conduct considerably more research into ameliorative interventions to help patients cope with the worst symptoms.
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Fallowfield, L., Jenkins, V. (2009). Quality of Life Issues During Adjuvant Endocrine Therapy. In: Castiglione, M., Piccart, M. (eds) Adjuvant Therapy for Breast Cancer. Cancer Treatment and Research, vol 151. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-75115-3_22
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