Surface Plasmon Resonance (SPR) Sensors for the Detection of Bacterial Pathogens

  • Allen D. Taylor
  • Jon Ladd
  • Jiří Homola
  • Shaoyi Jiang


Modern biosensor technologies can provide rapid quantification of bacterial pathogens. Surface plasmon resonance (SPR) sensors are an optical platform capable of highly sensitive and specific measuring of biomolecular interactions in real-time. This label-free technology can quantify the kinetics, affinity and concentration of surface interactions. SPR sensors have been used to detect bacterial pathogens in clinical and food-related samples. This chapter discusses the fundamental theory behind SPR sensors and state-of-the-art SPR instrumentation, surface chemistries, molecular recognition elements and detection strategies, as well as specific challenges associated with bacterial detection using SPR sensors. SPR-based detections of bacterial cells, genetic markers and antibody biomarkers are reviewed and discussed.


Surface Plasmon Resonance Apple Juice Domoic Acid Surface Plasmon Resonance Sensor Staphylococcal Enterotoxin 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Allen D. Taylor
    • 1
  • Jon Ladd
    • 1
  • Jiří Homola
    • 2
    • 3
  • Shaoyi Jiang
    • 1
  1. 1.Department of Chemical EngineeringUniversity of WashingtonUSA
  2. 2.Institute of Photonics and Electronics Academy of Sciences
  3. 3.Czech Republic and Department of Chemical EngineeringUniversity of WashingtonSeattleUSA

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