Molecular Imprinted Polymers for Biorecognition of Bioagents

  • Keith Warriner
  • Edward P.C. Lai
  • Azadeh Namvar
  • Daniel M. Hawkins
  • Subrayal M. Reddy


There is a trend in biohazard diagnostics to develop integrated systems to extract, concentration and detection from sample matrices. Although biological recognition agents, such as antibodies, can be applied for concentration and detection, there are several limitations. Specifically, biological recognition agents are hard to produce in large quantities, expensive and inherently unstable. Due to such limitations there has been a sustained interest in developing artificial or plastic antibodies that can be readily mass produced, highly stable and cheap. One of the most promising approaches to date has been in the area of Molecular Imprinted Polymers (MIP’s). In basic theory behind MIP’s is to form a polymer matrix around a template (analyte or structural surrogate) which is subsequently removed to leave voids with high affinity for the target analyte. To date, the majority of MIP research has focused on concentrating or detecting low molecular weight analytes in analytical chemistry. However, there has been interest in applying MIP’s to separate, concentrate or detect bioagents such as microbial metabolites, toxins, enzymes and even microbial cells. In the following chapter an overview on the principles of MIP will be outlined. The application of MIP’s as solid phase extraction matrices for separating and concentrating biological agents will be reviewed and recent advances described. The utility of MIP’s as biorecognition elements in biosensor devices will be covered. Finally, future directions in MIP research will be discussed and the main technological barriers to overcome identified.


Molecularly Imprint Polymer Functional Monomer Imprint Polymer Template Molecule Bovine Leukemia Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Keith Warriner
    • 1
  • Edward P.C. Lai
    • 2
  • Azadeh Namvar
    • 1
  • Daniel M. Hawkins
    • 3
  • Subrayal M. Reddy
    • 3
  1. 1.Department of Food ScienceUniversity of GuelphGuelphCanada
  2. 2.Ottawa-Carleton Chemistry Institute Department of ChemistryCarleton UniversityOttawaCanada
  3. 3.School of Biomedical and Molecular SciencesUniversity of SurreyGuildfordUK

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