Cantilever Sensors for Pathogen Detection
In this chapter we summarize briefly the use of cantilever sensors for pathogen detection. Both micro- and macro-cantilever sensors have been investigated for detecting pathogens in liquid samples. In this review we examine previous work and summarize progress on using piezoelectric-excited millimeter-sized cantilever (PEMC) sensors developed in the author’s laboratory. PEMC sensors immobilized with an antibody specific to the target pathogen has been shown to be very highly sensitive for detecting one cell per mL in one liter samples and 10 cells per mL in 10,mL samples, both in buffers and at similar concentrations in food matrices. After a brief introduction, the physics of sensing is reviewed, followed by a characterization of PEMC sensors, and finally the results from detection experiments are described.
KeywordsResonance Frequency Quartz Crystal Microbalance Piezoelectric Layer Bacillus Anthracis Ground Beef
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