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Porous and Planar Silicon Sensors

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Principles of Bacterial Detection: Biosensors, Recognition Receptors and Microsystems

Abstract

The development of novel sensors able to produce a response directly upon binding of a target biomolecular analyte remains a major area of research in materials science and analytical chemistry. As the primary “raw material” for the microelectronics industry, and because of its biocompatibility and optical properties, silicon has drawn considerable attention in this field. This chapter discusses the current state of efforts in our group and others to develop porous and planar sensors based on silicon. Porous silicon, so-called because of its complex three-dimensional network structure, provides a high internal binding surface and allows for observation of binding by changes in the reflectivity or luminescence spectra of single- or multi-layer devices. Planar silicon sensors, exemplified here by Arrayed Imaging Reflectometry (AIR), do not have the high surface area of porous silicon yet still respond with a high degree of sensitivity to the binding of analytes to the sensing surface. Examples are presented for the use of both types of sensors for the detection of DNA, proteins, and pathogenic bacteria.

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Authors and Affiliations

  1. University of Rochester, Rochester, New York, USA

    Charles R. Mace & Benjamin L. Miller

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  1. Charles R. Mace
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  2. Benjamin L. Miller
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Editors and Affiliations

  1. Biophage Pharma Inc, Montreal, Canada

    Mohammed Zourob

  2. Consultant to Biophage Pharma Inc, Montreal, Canada

    Souna Elwary

  3. Cranfield University, Bedfordshire, UK

    Anthony Turner

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Mace, C.R., Miller, B.L. (2008). Porous and Planar Silicon Sensors. In: Zourob, M., Elwary, S., Turner, A. (eds) Principles of Bacterial Detection: Biosensors, Recognition Receptors and Microsystems. Springer, New York, NY. https://doi.org/10.1007/978-0-387-75113-9_11

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  • DOI: https://doi.org/10.1007/978-0-387-75113-9_11

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