Based on much experimentation, traditional biochemists and molecular biologists have developed many qualitative models and hypotheses for biochemical pathway study [7, 26, 28]. However, in order to evaluate the completeness and usefulness of a hypothesis, produce predictions for further testing, and better understand the interaction and dynamic of pathway components, qualitative models are no longer adequate. There has recently been a focus on a more quantitative approach in systems biology study. In the past decade, numerous approaches for quantitative modeling of biochemical pathway dynamics have been proposed (e.g., [1, 4, 15, 29, 30, 34, 36], among others).
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He, F., Yeung, L.F., Brown, M. (2008). Discrete-Time Model Representations for Biochemical Pathways. In: Castillo, O., Xu, L., Ao, SI. (eds) Trends in Intelligent Systems and Computer Engineering. Lecture Notes in Electrical Engineering, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-74935-8_19
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