Muscle Oxygen Uptake Differs from Consumption Dynamics During Transients in Exercise

  • Nicola Lai
  • Nakisha Syed
  • Gerald M. Saidel
  • Marco E. Cabrera
Part of the Advances In Experimental Medicine And Biology book series (AEMB, volume 614)


Relating external to internal respiration during exercise requires quantitative modeling analysis for reliable inferences with respect to metabolic rate. Often, oxygen transport and metabolism based on steady-state mass balances (Fick principle) and passive diffusion between blood and tissue are applied to link pulmonary to cellular respiration. Indeed, when the work rate does not change rapidly, a quasi-steady-state analysis based on the Fick principle is sufficient to estimate the rate of O2 consumption in working muscle. During exercise when the work rate changes quickly, however, non-invasive in vivo measurements to estimate muscle O2 consumption are not sufficient to characterize cellular respiration of working muscle. To interpret transient changes of venous O2 concentration, blood flow, and O2 consumption in working muscle, a mathematical model of O2 transport and consumption based on dynamic mass balances is required. In this study, a comparison is made of the differences between simulations of O2 uptake and O2 consumption within working skeletal muscle based on a dynamic model and quasi-steady-state approximations. The conditions are specified under which the quasi-steadystate approximation becomes invalid.


Oxygen Transport Muscle Volume Muscle Blood Flow Muscle Oxygen Transient Term 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Nicola Lai
    • 1
    • 3
  • Nakisha Syed
    • 1
  • Gerald M. Saidel
    • 1
    • 3
  • Marco E. Cabrera
    • 1
    • 2
    • 3
  1. 1.Department of Biomedical EngineeringCleveland
  2. 2.Pediatrics, Center for Modeling Integrated Metabolism SystemsCleveland
  3. 3.Rainbow Babies and Children’s Hospital, Case Western Reserve UniversityClevelandUSA

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