Biomathematics in Cancer Detection: Simulation of Lipogenesis in Cancer

  • Ping Huang
  • Britton Chance
Part of the Advances In Experimental Medicine And Biology book series (AEMB, volume 614)


The usual mechanisms for biochemical events are steady-state systems without dynamic simulation. Our study is to simulate lipogenesis from the breakdown of glucose coupled with oxidative phosphorylation in mitochondria by using JSim (for Java Simulator) as software development environment, which enables non-linear differential equations to be used in a simulation giving a time course through a variety of non-steady-state conditions. Glycolysis and lipogenesis coupled with oxidative phosphorylation in mitochondria non-linear differential model is built in this paper. Simulation and discussion on lipogenesis by carbohydrate responsive element-binding protein (ChREBP) are given. Our model provides a potential way to analyze the experimental databank.


Oxidative Phosphorylation Cancer Detection Lipid Biosynthesis Usual Mechanism Software Development Environment 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Ping Huang
    • 1
  • Britton Chance
    • 1
  1. 1.Ping Huang and Britton Chance, Department of Biophysics and BiochemistryUniversity of PennsylvaniaPhiladelphia

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