A Simple Volume Related Model of Arterial Blood Pressure Generation

  • Christopher B. Wolff
  • Benn S. Gooch
  • James S. Douglas
Part of the Advances In Experimental Medicine And Biology book series (AEMB, volume 614)


A single compartment model of the arterial circulation was used to generate an arterial blood pressure waveform from pre-determined stroke volume (SV) and arterial resistance (R). With fixed stroke volume and varying resistances blood pressure waveforms showed mean values proportional to resistance but amplitude lessening with higher pressure; the amplitude of the hypothetical volume waveform of the arterial system was the same for all resistance values. Where SV varied and R changed reciprocally, the waveform when analysed with the PulseCO™ algorithm gave estimates slightly higher than the input stroke volumes (r 0.9998; y=0.99x + 5.28 ml). Where SV varied with fixed R mean blood pressure varied with stroke volume; SV estimates were, again, slightly higher than the input stroke volumes (r 0.9994; y=0.986x + ml). Estimates of SV andRfromValsalva manoeuvre BP were used in the model to generate arterial blood pressure. SV estimates closely resembled the original model values (r 0.988; y = 1.0802x − 3.9251). The model appears capable of generating BP waveforms compatible with real BP waveforms since stroke volume estimates closely resemble the original stroke volumes used in the model.


Stroke Volume Arterial Blood Pressure Vary Stroke Volume Hand Panel Arterial Resistance 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Christopher B. Wolff
    • 1
  • Benn S. Gooch
    • 2
  • James S. Douglas
    • 3
  1. 1.Clinical Pharmacology & Anaesthetics, William Harvey Research Institute, Barts and The Royal LondonLondonUK
  2. 2.St. George’s, University of London, Cranmer TerraceLondonUK
  3. 3.LiDCO Ltd, Unit MCambridgeUK

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