Retinal degeneration caused blindness, such as age-related macular degeneration (AMD), diabetic retinopathy (DR), retinitis pigmentosa (RP) and retinal detachment, is a major problem in clinical ophthalmology.Although genetic modifications are responsible for most retinal degenerative diseases, there is increasing evidence showing that reactive oxygen intermediates (ROIs), the byproducts of the oxidative metabolic reactions, are closely involved in the process of photoreceptor cell degeneration (Beatty et al., 2000; Maeda et al., 2005; Wenzel et al., 2005). These ROIs, including hydrogen peroxide, hypochlorite ions, hydroxyl radicals, hydroxyl ions and superoxide anions (Beatty et al., 2000), react with almost any nearby DNA, RNA, lipid, carbohydrate or protein. They are produced primarily by the normal oxidative metabolism that occurs in the mitochondrial respiratory chain.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Beatty, S., Koh, H., Phil, M., Henson, D. & Boulton, M., 2000, The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv. Ophthalmol. 45:115–134.
Caldwell, R.B., Bartoli, M., Behzadian, M.A., El-Remessy, A.E., Al-Shabrawey, M., Platt, D.H. & Caldwell, R.W., 2003, Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives. Diabetes Metab. Res. Rev. 19:442–455.
Cao, W., Tombran-Tink, J., Elias R., Sezate S., Mrazek, D. & McGinnis, J.F., 2001, In vivo protection of photoreceptors from light damage by pigment epithelium derived factor. Invest Ophthalmol. Vis. Sci. 42:1646–1652.
Chen, J., Patil, S., Seal, S. & McGinnis, J.F., 2006, Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxidase. Nature Nanotech. 1:142–150.
Conesa, J.C., 1995, Computer modeling of surfaces and defects on cerium dioxide. Surf. Sci. 339:337–352.
Deshpande, 2005, Size dependency variation in lattice parameter and valency states in nanocrystalline cerium oxide. Appl. Phys. Lett. 87:1–3.
Emerit, J., Edeas, M. & Bricaire, F., 2004, Neurodegenerative diseases and oxidative stress. Biomed. Pharmacother. 58:39–46.
Herman, G.S., 1999, Characterization of surface defects on epitaxial CeO2(001) films. Surf. Sci. 437:207–214.
Kosacki, I., Suzuki, T., Anderson, H.U. & Colomban, P., 2002, Raman scattering and lattice defects in nanocrystalline CeO2 thin films. Solid State Ionics 149:99–105.
LeBel, C.P., Ischiropoulos, H. & Bondy, S.C., 1992, Evaluation of the probe 20,70-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem. Res. Toxicol. 5:227–231.
Lewis, G.P., Erickson, P.A., Anderson, D.H. & Fisher, S.K., 1991, Opsin distribution and protein incorporation in photoreceptors after experimental retinal detachment. Exp. Eye Res. 53:629–640.
Maeda, A., Crabb, J.W. & Palczewski, K., 2005, Microsomal glutathione S-transferase 1 in the retinal pigment epithelium: protection against oxidative stress and a potential role in aging. Biochemistry. 44(2):480–489.
Mamontov, E., Egami, T., Brezay, R., Koranne, M. & Tyagi, S., 2000, Lattice defects and oxygen storage capacity of nanocrystalline ceria and ceria-zirconia. J. Phys. Chem. 104:1110–1116.
McGinnis, J.F., Stepanik, P.L., Chen W., Elias R., Cao W. & Lerious V., 1999, Unique retina cell phenotypes revealed by immunological analysis of recoverin expression in rat retina cells. J. Neurosci. Res. 55:252–260.
Patil, S., Seal, S., Guo, Y., Schulte, A. & Norwood, J., 2006, Role of trivalent La and Nd dopants in lattice distortion and oxygen vacancy generation in cerium oxide nanoparticles. Appl. Phys. Lett. 88:1–3.
Suzuki, T., Kosacki, I., Anderson, H.U. & Colomban, P., 2001, Electrical conductivity and lattice defects in nanocrystalline cerium oxide thin films. J. Am. Ceram. Soc. 84:2007–2014.
Wenzel, A., Grimm, C., Samardzija, M. & Reme, C.E., 2005, Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. Progr. Retial Eye Res. 24:275–306.
Yu, D. & Cringle., S.J., 2005, Retinal degeneration and local oxygen metabolism. Exp. Eye Res. 80:745–751.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Chen, J., Patil, S., Seal, S., McGinnis, J.F. (2008). Nanoceria Particles Prevent ROI-Induced Blindness. In: Anderson, R.E., LaVail, M.M., Hollyfield, J.G. (eds) Recent Advances in Retinal Degeneration. Advances in Experimental Medicine and Biology, vol 613. Springer, New York, NY. https://doi.org/10.1007/978-0-387-74904-4_5
Download citation
DOI: https://doi.org/10.1007/978-0-387-74904-4_5
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-74902-0
Online ISBN: 978-0-387-74904-4
eBook Packages: MedicineMedicine (R0)