Nanoceria Particles Prevent ROI-Induced Blindness
Retinal degeneration caused blindness, such as age-related macular degeneration (AMD), diabetic retinopathy (DR), retinitis pigmentosa (RP) and retinal detachment, is a major problem in clinical ophthalmology.Although genetic modifications are responsible for most retinal degenerative diseases, there is increasing evidence showing that reactive oxygen intermediates (ROIs), the byproducts of the oxidative metabolic reactions, are closely involved in the process of photoreceptor cell degeneration (Beatty et al., 2000; Maeda et al., 2005; Wenzel et al., 2005). These ROIs, including hydrogen peroxide, hypochlorite ions, hydroxyl radicals, hydroxyl ions and superoxide anions (Beatty et al., 2000), react with almost any nearby DNA, RNA, lipid, carbohydrate or protein. They are produced primarily by the normal oxidative metabolism that occurs in the mitochondrial respiratory chain.
KeywordsDiabetic Retinopathy Retinitis Pigmentosa Photoreceptor Cell Cerium Oxide Retinal Degeneration
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- Caldwell, R.B., Bartoli, M., Behzadian, M.A., El-Remessy, A.E., Al-Shabrawey, M., Platt, D.H. & Caldwell, R.W., 2003, Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives. Diabetes Metab. Res. Rev. 19:442–455.PubMedCrossRefGoogle Scholar
- Kosacki, I., Suzuki, T., Anderson, H.U. & Colomban, P., 2002, Raman scattering and lattice defects in nanocrystalline CeO2 thin films. Solid State Ionics 149:99–105.Google Scholar
- Mamontov, E., Egami, T., Brezay, R., Koranne, M. & Tyagi, S., 2000, Lattice defects and oxygen storage capacity of nanocrystalline ceria and ceria-zirconia. J. Phys. Chem. 104:1110–1116.Google Scholar