Advertisement

CNTF Negatively Regulates the Phototransduction Machinery in Rod Photoreceptors: Implication for Light-Induced Photostasis Plasticity

  • Rong Wen
  • Ying Song
  • Yun Liu
  • Yiwen Li
  • Lian Zhao
  • Alan M. Laties
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 613)

CNTF is a member of the interleukin-6 (IL-6) family of neuropoietic cytokines, which includes IL-6, IL-11, LIF (leukemia inhibitory factor), OsM (oncostatin M), and CT-1 (cardiotropin 1).

Keywords

Retinal Degeneration CNTF Treatment Rhodopsin Content Continual Renewal Neuropoietic Cytokine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bargoot, F. G., Williams, T. P. and Beidler, L. M., 1969, The localization of radioactive amino acid taken up into the outer segments of frog (Rana pipiens) rods. Vision Res 9:385–391.PubMedCrossRefGoogle Scholar
  2. Battelle, B. A. and LaVail, M. M., 1978, Rhodopsin content and rod outer segment length in albino rat eyes: modification by dark adaptation. Exp Eye Res 26:487–497.PubMedCrossRefGoogle Scholar
  3. Berson, D. M., Dunn, F. A. and Takao, M., 2002, Phototransduction by retinal ganglion cells that set the circadian clock. Science 295:1070–1073.PubMedCrossRefGoogle Scholar
  4. Bok, D., Yasumura, D., Matthes, M. T., Ruiz, A., Duncan, J. L., Chappelow, A. V., Zolutukhin, S., Hauswirth, W. and LaVail, M. M., 2002, Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation. Exp Eye Res 74:719–735.PubMedCrossRefGoogle Scholar
  5. Farber, D. B., Danciger, J. S. and Organisciak, D. T., 1991, Levels of mRNA encoding proteins of the cGMP cascade as a function of light environment. Exp Eye Res 53:781–786.PubMedCrossRefGoogle Scholar
  6. Fulton, A. B. and Rushton, W. A., 1978, The human rod ERG: correlation with psychophysical responses in light and dark adaptation. Vision Res 18:793–800.PubMedCrossRefGoogle Scholar
  7. Hall, M. O., Bok, D. and Bacharach, A. D., 1969, Biosynthesis and assembly of the rod outer segment membrane system. Formation and fate of visual pigment in the frog retina. J Mol Biol 45:397–406.PubMedCrossRefGoogle Scholar
  8. LaVail, M. M., Unoki, K., Yasumura, D., Matthes, M. T., Yancopoulos, G. D. and Steinberg, R. H., 1992, Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc Natl Acad Sci U S A 89:11249–11253.PubMedCrossRefGoogle Scholar
  9. Liang, F. Q., Aleman, T. S., Dejneka, N. S., Dudus, L., Fisher, K. J., Maguire, A. M., Jacobson, S. G. and Bennett, J., 2001, Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa. Mol Ther 4:461–472.PubMedCrossRefGoogle Scholar
  10. Organisciak, D. T. and Noell, W. K., 1977, The rod outer segment phospholipid/opsin ratio of rats maintained in darkness or cyclic light. Invest Ophthalmol Vis Sci 16:188–190.PubMedGoogle Scholar
  11. Organisciak, D. T., Xie, A., Wang, H. M., Jiang, Y. L., Darrow, R. M. and Donoso, L. A., 1991, Adaptive changes in visual cell transduction protein levels: effect of light. Exp Eye Res 53: 773–779.PubMedCrossRefGoogle Scholar
  12. Penn, J. S. and Williams, T. P., 1986, Photostasis: regulation of daily photon-catch by rat retinas in response to various cyclic illuminances. Exp Eye Res 43:915–928.PubMedCrossRefGoogle Scholar
  13. Peterson, W. M., Wang, Q., Tzekova, R. and Wiegand, S. J., 2000, Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia. J Neurosci 20: 4081–4090.PubMedGoogle Scholar
  14. Reiser, M. A., Williams, T. P. and Pugh, E. N., Jr., 1996, The effect of light history on the aspartate-isolated fast-PIII responses of the albino rat retina. Invest Ophthalmol Vis Sci 37:221–229.PubMedGoogle Scholar
  15. Schlichtenbrede, F. C., MacNeil, A., Bainbridge, J. W., Tschernutter, M., Thrasher, A. J., Smith, A. J. and Ali, R. R., 2003, Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration. Gene Ther 10:523–527.PubMedCrossRefGoogle Scholar
  16. Wen, R., Song, Y., Kjellstrom, S., Tanikawa, A., Liu, Y., Li, Y., Zhao, L., Bush, R. A., Laties, A. M. and Sieving, P. A., 2006, Regulation of rod phototransduction machinery by ciliary neurotrophic factor. J Neurosci 26:13523–13530.PubMedCrossRefGoogle Scholar
  17. Young, R. W., 1967, The renewal of photoreceptor cell outer segments. J Cell Biol 33:61–72.PubMedCrossRefGoogle Scholar
  18. Young, R. W. and Droz, B., 1968, The renewal of protein in retinal rods and cones. J Cell Biol 39:169–184.PubMedCrossRefGoogle Scholar
  19. Young, R. W. and Bok, D., 1969, Participation of the retinal pigment epithelium in the rod outer segment renewal process. J Cell Biol 42:392–403.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Rong Wen
    • 1
  • Ying Song
    • 1
  • Yun Liu
    • 1
  • Yiwen Li
    • 1
  • Lian Zhao
    • 1
  • Alan M. Laties
    • 1
  1. 1.Department of OphthalmologyUniversity of Pennsylvania, School of MedicinePhiladelphia

Personalised recommendations