A2E, A Pigment of RPE Lipofuscin, is Generated from the Precursor, A2PE by a Lysosomal Enzyme Activity

  • Janet R. Sparrow
  • So Ra Kim
  • Ana M. Cuervo
  • Urmi Bandhyopadhyayand
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 613)

The lipofuscin that accumulates in retinal pigment epithelial cells with age and that is abundant in some retinal disorders, is sequestered within the interior of membrane bound organelles of the lysosomal compartment of the cell. RPE lipofuscin pigments form in large part due to reactions of vitamin A aldehyde.


Retinal Pigment Epithelial Cell Outer Segment Photoreceptor Outer Segment Human Retinal Pigment Epithelium Protease Inhibitor Mixture 


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Janet R. Sparrow
    • 1
  • So Ra Kim
  • Ana M. Cuervo
    • 2
  • Urmi Bandhyopadhyayand
    • 2
  1. 1.Departments of OphthalmologyPathology and Cell Biology, Columbia UniversityNew York
  2. 2.Department of Anatomy and Structural BiologyAlbert Einstein College of MedicineBronx

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