A2E, A Pigment of RPE Lipofuscin, is Generated from the Precursor, A2PE by a Lysosomal Enzyme Activity
The lipofuscin that accumulates in retinal pigment epithelial cells with age and that is abundant in some retinal disorders, is sequestered within the interior of membrane bound organelles of the lysosomal compartment of the cell. RPE lipofuscin pigments form in large part due to reactions of vitamin A aldehyde.
KeywordsRetinal Pigment Epithelial Cell Outer Segment Photoreceptor Outer Segment Human Retinal Pigment Epithelium Protease Inhibitor Mixture
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