Variation in the Electroretinogram of C57BL/6 Substrains of Mouse
The electroretinogram (ERG) is one of the most commonly used clinical techniques to measure visual function. The ERG records the impulse generated by retinal cells in response to a single flash of light (Fishman et al., 2001). By altering the light or dark adapted status of the subject and recording at different light intensities and/or flicker frequencies, rod and cone function can be recorded and analysed in isolation, as can the function of second order neurons (Marmor et al., 2004). The ERG is a complex waveform and alterations can be used to diagnose and follow the progress of a variety of retinal disorders. Since this system is non-invasive, it can also be adapted to record from anaesthetised mice, specifically those with either spontaneous or targeted mutations in retinal genes (Nusinowitz and Ridder , 2002; Peachey and Ball, 2003).
KeywordsOscillatory Potential Retinal Degeneration Outer Nuclear Layer Synuclein Alpha Roland Consult
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