Retinal prosthetics are designed to restore vision in patients with photoreceptor degenerative diseases, such as retinitis pigmentosa (RP) and macular degeneration. Subretinal microphotodiode arrays (MPAs), which response to incident light in a gradient fashion, have been designed to replace degenerating photoreceptors. Such devices have been implanted into rats (Ball et al., 2001), cats (Chow et al., 2001) and humans (Chow et al., 2004). These studies have revealed that implantation of a MPA device is capable of restoring some visual function in patients (Chow et al., 2004) and eliciting a superior colliculus response in normal and degenerating rats (DeMarco et al., 2007). Furthermore, the low level electrical stimulation produced by the MPA device has been shown to have neuroprotective properties (Pardue et al., 2005).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ball, S.L., Pardue, M.T., Chow, A.Y., Chow, V.Y., and Peachey, N.S., 2001, Subretinal implantation of photodiodes in rodent models of photoreceptor degeneration, In: New Insights into Retinal Degenerative Diseases, R.E. Anderson, M.M. LaVail, and J.G. Hollyfield, eds., Kluwer/Plenum, New York, pp.175–182.
Chang, B., Hawes, N.L., Hurd, R.E., Davisson, M.T., Nusinowitz, S., and Heckenlively, J.R., 2002, Retinal degeneration mutants in the mouse. Vision Res. 42:517–25.
Chow, A.Y., Pardue, M.T., Chow, V.Y., Peyman, G.A., Liang, C., Perlman, J.I., and Peachey, N.S., 2001, Implantation of silicon chip microphotodiode arrays into the cat subretinal space. IEEE Trans. Neural Syst. Rehabil. Eng. 9:86–95.
Chow, A.Y., Pardue, M.T., Perlman, J.I., Ball, S.L., Chow, V.Y., Hetling, J.R., Peyman G.A., Liang, C., Stubbs, E.B., Jr., and Peachey, N.S., 2002, Subretinal implantation of semiconductor-based photodiodes: durability of novel implant designs. J. Rehabil. Res. Dev. 39:313–321.
Chow, A.Y., Chow, V.Y., Peyman, G.A., Packo, K.H., Pollack, J.S., and Schuchard, R., 2004, The artificial silicon retinaTM (ASRTM) chip for the treatment of vision loss from retinitis pigmentosa. Arch. Ophthalmol. 122:460–469.
Ciavatta, V.T., Chrenek, M., Wong, P., Nickerson, J.M., and Pardue, M.T., 2006, Growth factor expression following implantation of microphotodiode arrays in RCS rats. ARVO E-abstract 3177.
Dalke, C., and Graw, J., 2005, Mouse mutants as models for congenital retinal disorders. Exp. Eye Res. 81:503–512.
D&’Cruz, P.M., Yasumura, D., Weir, J., Matthes, M.T., Abderrahim, H., LaVail, M.M., and Vollrath, D., 2000, Mutation of the receptor tyrosine kinase gene MertK in the retina dystrophic RCS rat. Hum. Mol. Genet. 9:645–51.
DeMarco, P.J., Jr., Yarbrough, G.L., Yee, C.W., McLean, G.Y., Sagdullaev, B.T., Ball, S.L., and McCall, M.A., 2007, Stimulation via a subretinally placed prosthetic elicits central activity and induces a trophic effect on visual responses. Invest. Ophthalmol. Vis. Sci. 48:916–26.
Lee, D., Geller, S., Walsh, N., Valter, K., Yasumura, D., Matthes, M., LaVail, M., and Stone, J., 2003, Photoreceptor degeneration in Pro23His and S334ter transgenic rats. Adv. Exp. Med. Biol. 533:297–302.
Mullen, R.J., and LaVail, M.M., 1976, Inherited retinal dystrophy: primary defect in pigment epithelium determined with experiment rat chimeras. Science 192:799–801.
Pardue, M.T., Phillips, M.J., Yin, H., Sippy, B.D., Webb-wood, S., Chow, A.Y., and Ball, S.L., 2005, Neuroprotective effect of subretinal implants in the RCS rat. Invest. Ophthalmol. Vis. Sci. 46:674–682.
Pardue, M.T., Stubbs, E.B., Jr., Perlman, J.I., Narfstrom, K., Chow, A.Y., and Peachey, N.S., 2001, Immunohistochemical studies of the retina following long-term implantation with subretinal microphotodiode arrays. Exp. Eye Res. 73:333–343.
Turner, P.V., and Albassam, M.A., 2005, Susceptiblity of rats to corneal lesions after injectable anesthesia. Comp. Med. 55:175–182.
Walker, T.A., Faulkner, A.E., Cheng, Y., Yin, H., Fernandes, A., Phillips, M.J., Ball, S.L., Chow, A.Y., and Pardue, M.T., 2005, Subretinal implantation induces photoreceptor preservation in RCS rat not seen in wild-type long evans or S334ter rats. ARVO E-Abstract 5267.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Pardue, M.T., Walker, T.A., Faulkner, A.E., Kim, M.K., Bonner, C.M., McLean, G.Y. (2008). Implantation of Mouse Eyes with a Subretinal Microphotodiode Array. In: Anderson, R.E., LaVail, M.M., Hollyfield, J.G. (eds) Recent Advances in Retinal Degeneration. Advances in Experimental Medicine and Biology, vol 613. Springer, New York, NY. https://doi.org/10.1007/978-0-387-74904-4_44
Download citation
DOI: https://doi.org/10.1007/978-0-387-74904-4_44
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-74902-0
Online ISBN: 978-0-387-74904-4
eBook Packages: MedicineMedicine (R0)