Implantation of Mouse Eyes with a Subretinal Microphotodiode Array
Retinal prosthetics are designed to restore vision in patients with photoreceptor degenerative diseases, such as retinitis pigmentosa (RP) and macular degeneration. Subretinal microphotodiode arrays (MPAs), which response to incident light in a gradient fashion, have been designed to replace degenerating photoreceptors. Such devices have been implanted into rats (Ball et al., 2001), cats (Chow et al., 2001) and humans (Chow et al., 2004). These studies have revealed that implantation of a MPA device is capable of restoring some visual function in patients (Chow et al., 2004) and eliciting a superior colliculus response in normal and degenerating rats (DeMarco et al., 2007). Furthermore, the low level electrical stimulation produced by the MPA device has been shown to have neuroprotective properties (Pardue et al., 2005).
KeywordsRetinitis Pigmentosa Retinal Degeneration Retinal Function Subretinal Space Photoreceptor Degeneration
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