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Regulation of Neurotrophin Expression and Activity in the Retina

  • Abigail S. Hackam
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 613)

Growth factors and their receptors are upregulated during retinal degeneration as an intrinsic tissue response that may protect remaining photoreceptors (Harada et al., 2002;Wen et al., 1995;Yu et al., 2004).Growth factor delivery to animal models of retinal degeneration leads to various degrees of preservation of photoreceptor morphology and function (Chaum, 2003). A major class of neuroprotective growth factors in the retina are the neurotrophinsNGF, BDNF, NT3 and NT4/5. Therapeutic use of these molecules is complicated by their ability to activate pro-death as well as pro-survival pathways.

Keywords

Retinal Degeneration Neurotrophin Receptor Upstream Stimulatory Factor Growth Factor Delivery Neurotrophin Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Abigail S. Hackam
    • 1
  1. 1.Bascom Palmer Eye Institute, University of MiamiMiller School of MedicineMiami

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