Regulation of Neurotrophin Expression and Activity in the Retina
Growth factors and their receptors are upregulated during retinal degeneration as an intrinsic tissue response that may protect remaining photoreceptors (Harada et al., 2002;Wen et al., 1995;Yu et al., 2004).Growth factor delivery to animal models of retinal degeneration leads to various degrees of preservation of photoreceptor morphology and function (Chaum, 2003). A major class of neuroprotective growth factors in the retina are the neurotrophinsNGF, BDNF, NT3 and NT4/5. Therapeutic use of these molecules is complicated by their ability to activate pro-death as well as pro-survival pathways.
KeywordsRetinal Degeneration Neurotrophin Receptor Upstream Stimulatory Factor Growth Factor Delivery Neurotrophin Expression
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