On the Role of CNTF as a Pontential Therapy for Retinal Degeneration: Dr. Jekyll or Mr. Hyde?

  • William A. Beltran
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 613)

Among the various neuroprotective agents, ciliary neurotrophic factor (CNTF) has been themost tested compound in animal models of retinal degeneration. CNTF was initially isolated from the chick eye as a soluble factor that promotes the survival of dissociated ciliary ganglionic neurons of 12-day chick embryos (Adler et al., 1979). Its use as a neuroprotective agent for the retina was first tested in rats 15 years ago in a light-damage model of retinal degeneration (LaVail et al., 1992). Since then, numerous studies conducted in a variety of animal models have demonstrated CNTF’s pro-survival effect on photoreceptor cells.


Retinitis Pigmentosa Photoreceptor Cell Retinal Degeneration Ciliary Neurotrophic Factor Photoreceptor Degeneration 
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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Section of Ophthalmology, Department of Clinical StudiesSchool of Veterinary Medicine, University of PennsylvaniaPhiladelphiaUSA

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