On the Role of CNTF as a Pontential Therapy for Retinal Degeneration: Dr. Jekyll or Mr. Hyde?
Among the various neuroprotective agents, ciliary neurotrophic factor (CNTF) has been themost tested compound in animal models of retinal degeneration. CNTF was initially isolated from the chick eye as a soluble factor that promotes the survival of dissociated ciliary ganglionic neurons of 12-day chick embryos (Adler et al., 1979). Its use as a neuroprotective agent for the retina was first tested in rats 15 years ago in a light-damage model of retinal degeneration (LaVail et al., 1992). Since then, numerous studies conducted in a variety of animal models have demonstrated CNTF’s pro-survival effect on photoreceptor cells.
KeywordsRetinitis Pigmentosa Photoreceptor Cell Retinal Degeneration Ciliary Neurotrophic Factor Photoreceptor Degeneration
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- Beltran, W.A., Wen, R., Acland, G.M., Aguirre, G.D., 2007. Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina. Exp Eye Res. 148: 53–64.Google Scholar
- Liang, F.Q., Aleman, T.S., Dejneka, N.S., Dudus, et al., 2001a. Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa. Mol Ther. 4: 461–472.Google Scholar
- Liang, F.Q., Dejneka, N.S., Cohen, D.R., Krasnoperova, N.V., et al., 2001b. AAV-mediated delivery of CNTF prolongs photoreceptor survival in the rhodopsin knockout mouse. Mol Ther. 3: 241–248.Google Scholar
- Schlichtenbrede, F.C., MacNeil, A., Bainbridge, J.W., Tschernutter, M., et al., 2003. Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration. Gene Ther. 10: 523–527.PubMedCrossRefGoogle Scholar