Analysis of the Rate of Disk Membrane Digestion by Cultured RPE Cells

  • Tanja Diemer
  • Daniel Gibbs
  • David S. Williams
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 613)

The retinal pigment epithelium (RPE) is a monolayer of polarized cells localized between the photoreceptor cell layer and Bruch’s membrane. As part of an essential photoreceptor outer segment (ROS) renewal process, the RPE cells phagocytose and degrade the distal ROS disk membranes on a daily basis. It is hypothesized that even a minor delay in uptake or clearance of the daily outer segment load by the RPE can result in the accumulation of undigested material and ensuing retinal damage.


Retinal Pigment Epithelium Retinal Pigment Epithelium Cell Outer Segment ARPE19 Cell Usher Syndrome 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Tanja Diemer
    • 1
  • Daniel Gibbs
    • 2
  • David S. Williams
    • 1
  1. 1.Departments of Pharmacology and NeurosciencesUCSD School ofMedicineLa JollaUSA
  2. 2.Department of Ophthalmology and Visual Sciences, Departments of Pharmacology and NeurosciencesMoran Eye Center and Program in Human Molecular Biology and Genetics, UCSD School of Medicine, University of Utah School of MedicineLa Jolla, Salt Lake CityUSA

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