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Organization and Molecular Interactions of Retinoschisin in Photoreceptors

  • Camasamudram Vijayasarathy
  • Yuichiro Takada
  • Yong Zeng
  • Ronald A. Bush
  • Paul A. Sieving
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 613)

Retinoschisin (RS), the product of the RS1 gene on the X-chromosome (Xp22), is a 24 kDa secreted protein which is expressed exclusively in the retina (Reid et al., 1999; Sauer et al., 1997) and pineal gland (Takada et al., 2006). In the retina, photoreceptors, bipolar cells, and ganglion cells synthesize RS (Takada et al., 2004). The structural features and functional implications of the 224 amino acid RS sequence include a N-terminus signal peptide (amino acids 1–23) and a 157 amino acid (amino acids 68–217) discoidin domain (Reid et al., 1999; Sauer et al., 1997). The signal peptide guides the secretion of mature RS across the plasma membrane and is cleaved off during the translocation process (Molday, 2007).

Keywords

Outer Segment Mouse Retina Discoidin Domain Receptor Peripheral Membrane Protein Murine Retina 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Camasamudram Vijayasarathy
    • 1
  • Yuichiro Takada
    • 1
  • Yong Zeng
    • 1
  • Ronald A. Bush
    • 1
  • Paul A. Sieving
    • 2
  1. 1.Section for Translational Research in Retinal and Macular DegenerationNational Institute on Deafness and other Communication Disorders,National Institutes of HealthBethesdaUSA
  2. 2.National Eye Institute; National Institutes of HealthBethesdaUSA

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