Role of ELOVL4 in Fatty Acid Metabolism

  • Vidyullatha Vasireddy
  • Majchrzak Sharon
  • Norman SalemJr
  • Radha Ayyagari
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 613)

Stargardt like macular dystrophy (STGD3) is an inherited form of early onset autosomal dominant macular degeneration. Pathophysiology of STGD3 is associated with the loss of central vision and RPE atrophy. Accumulation of lipofuscin was observed with the progression of the disease (Stone et al., 1994; Griesinger et al., 2000). Mutations in a novel gene, elongation of very long chain fatty acid-4 (ELOVL4) were found to be associated with STGD3 (Zhang et al., 2001).


Fatty Acid Metabolism Very Long Chain Fatty Acid Macular Dystrophy Brain Fatty Acid Epidermal Permeability Barrier 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Vidyullatha Vasireddy
    • 1
  • Majchrzak Sharon
    • 2
  • Norman SalemJr
    • 2
  • Radha Ayyagari
    • 3
  1. 1.Ophthalmology and Visual Sciences, W. K. Kellogg Eye CenterUniversity of MichiganAnn Arbor
  2. 2.Laboratory of Membrane Biochemistry and Biophysics, NIAAANational Institutes of HealthBethesda
  3. 3.Ophthalmology and Visual Sciences, W. K. Kellogg Eye CenterUniversity of MichiganAnn Arbor

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