A Possible Impaired Signaling Mechanism in Human Retinal Pigment Epithelial Cells from Patients with Macular Degeneration

  • Piyush C. Kothary
  • Monte A. Del Monte
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 613)

The human retinal pigment epithelial (hRPE) cells form a monolayer of polarized cells in the posterior segments of human eyes. They play an important role in the flow of nutrients from the choroid to the neural retina. They normally are mitotically inactive in adult human eyes. Pathological proliferation in later life has been implicated in the pathogenesis of age related macular degeneration (AMD) (Hamdi et al., 2003; Tezel et al., 2004; Zarbin, 2006)


Retinal Pigment Epithelial Macular Degeneration Neural Retina Human Retinal Pigment Epithelial Cell hRPE Cell 
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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Kellogg Eye CenterUniversity of MichiganAnn Arbor
  2. 2.Kellogg Eye CenterUniversity of MichiganAnn Arbor

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