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10q26 Is Associated with Increased Risk of Age-Related Macular Degeneration in the Utah Population

  • D. Joshua Cameron
  • Zhenglin Yang
  • Zhongzhong Tong
  • Yu Zhao
  • Alissa Praggastis
  • Eric Brinton
  • Jennifer Harmon
  • Yali Chen
  • Erik Pearson
  • Paul S. Bernstein
  • Gregory Brinton
  • Xi Li
  • Adam Jorgensen
  • Sara Schneider
  • Daniel Gibbs
  • Haoyu Chen
  • Changguan Wang
  • Kimberly Howes
  • Nicola J. Camp
  • Kang Zhang
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 613)

Age-related macular degeneration (AMD) includes a wide range of phenotypes. Early AMD is mainly characterized by the presence of soft dusen in the macula without visual loss, while advanced AMD is characterized by geographic atrophy (GA or dry AMD) and neovascular AMD (wet AMD) with visual loss. Despite the rising prevalence of AMD as a result of increasing life expectancy, its underlying etiology is poorly understood and there is no specific therapy.

Keywords

Geographic Atrophy LOC388715 Rs10490924 Disease Haplotype Utah Population Locus Odds Ratio 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • D. Joshua Cameron
    • 1
  • Zhenglin Yang
    • 1
  • Zhongzhong Tong
    • 1
  • Yu Zhao
    • 1
  • Alissa Praggastis
    • 1
  • Eric Brinton
    • 1
  • Jennifer Harmon
    • 1
  • Yali Chen
    • 1
  • Erik Pearson
    • 1
  • Paul S. Bernstein
    • 1
  • Gregory Brinton
  • Xi Li
    • 1
  • Adam Jorgensen
  • Sara Schneider
    • 1
  • Daniel Gibbs
    • 1
  • Haoyu Chen
    • 1
  • Changguan Wang
    • 1
  • Kimberly Howes
    • 1
  • Nicola J. Camp
    • 1
  • Kang Zhang
    • 1
  1. 1.Department of Ophthalmology and Visual Sciences, Moran Eye Center and Program in Human Molecular Biology and GeneticsUniversity of Utah School of MedicineSalt Lake CityUSA

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