10q26 Is Associated with Increased Risk of Age-Related Macular Degeneration in the Utah Population
Age-related macular degeneration (AMD) includes a wide range of phenotypes. Early AMD is mainly characterized by the presence of soft dusen in the macula without visual loss, while advanced AMD is characterized by geographic atrophy (GA or dry AMD) and neovascular AMD (wet AMD) with visual loss. Despite the rising prevalence of AMD as a result of increasing life expectancy, its underlying etiology is poorly understood and there is no specific therapy.
KeywordsGeographic Atrophy LOC388715 Rs10490924 Disease Haplotype Utah Population Locus Odds Ratio
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