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Genetics of Age-related Macular Degeneration

  • Albert O. Edwards
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 613)

There have been major advances over the past two years in identifying genetic risks for age-related macular degeneration (AMD). The complexity of genetic association and genetic epidemiology studies and differences in the conclusions and data reported from various laboratories make it difficult for the general scientific reader to understand the significance and limitations of these advances. Thus, the scientific foundations and limitations of these genetic studies are not widely understood. The general scientific reader needs an approach to recognize spurious genetic association from those that are real and to understand what genetic association studies can teach us about AMD and where we need to be cautious. The purpose of this article is to provide an overview of the genetics of AMD and explain how to approach a genetic association study.

Keywords

Genetic Association Study Geographic Atrophy Protective Haplotype Extensive Linkage Disequilibrium Chromosome 10q26 Locus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Department of OphthalmologyMayo ClinicRochester

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