The Potential of Ambient Light Restriction to Restore Function to the Degenerating P23H-3 Rat Retina
Reviewing, in 1999, the non-genetic factors that regulate retinal degeneration, we (Stone et al., 1999) hypothesized that the loss of vision during degeneration results only partly from photoreceptor death. Significant visual loss results, we argued, from loss of performance in surviving photoreceptors, and might be reversible. To test the idea, we first demonstrated that, in the rhodopsin-mutant P23H-3 transgenic rat, the retina is hypersensitive to modest levels of ambient light, which accelerate photoreceptor death, shorten outer segments and degrade the ERG more severely than in non-degenerative controls (Walsh et al., 2004). A comparable hypersensitivity to ambient light has since been reported in a rhodopsin-mutant degeneration which occurs naturally in the dog (Cideciyan et al., 2005).
KeywordsRetinitis Pigmentosa Outer Segment Ambient Light Retinal Degeneration Light Restriction
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- Johnson G (1901) Contributions to the comparative anatomy of the mammalian eye chiefly based on ophthalmoscopic examination. Phil Trans Roy Soc London 194.Google Scholar
- Kaitz M (1976) Protection of the dystrophic retina from susceptibility to light stress. Invest Ophthalmol 15: 153–156.Google Scholar
- Penn JS (1998) Early studies of the photostasis phenomenon. In: Photostasis and Related Phenomenon. Plenum Press, New York, pp 1–16.Google Scholar
- Williams TP (1998) Light history and photostastis. In: Photostasis and Related Phenomena. Plenum Press, New York, pp 17–32.Google Scholar