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Oxygen Supply and Retinal Function: Insights from a Transgenic Animal Model

  • Edda Fahl
  • Max Gassmann
  • Christian Grimm
  • Mathias W. Seeliger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 613)

Transportation of oxygen to the different retinal layers occurs via two major vascular systems present in the eye. The supply of the outer retina originates in the choroid (choriocapillaris) located beneath the retinal pigment epithelium (RPE). The retinal circulation supplies the inner retina and as shown by Cuthbertson (1986), exists in three capillary beds centered on the nerve-fibre layer, the junction of inner plexiform and inner nuclear layer, and the outer plexiform layer. Alder (1990) found that a typical PO2 profile starts at 82 mm Hg at the choroidal side of the retina. With increasing distance of the retinal layers to the choroid the PO2 value decreases to 2 mm Hg at the balance point of the two circulations and increases up to 15 mm Hg due to the retinal circulation.

Keywords

Retinal Pigment Epithelium Retinal Layer Retinal Degeneration Retinal Function Outer Plexiform Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Edda Fahl
    • 1
  • Max Gassmann
    • 2
  • Christian Grimm
    • 3
  • Mathias W. Seeliger
    • 4
  1. 1.Ocular Neurodegeneration Research GroupCentre for Ophthalmology, Institute for Ophthalmic ResearchGermany D-72076
  2. 2.Institute of Veterinary PhysiologyUniversity Eye HospitalZurichSwitzerland
  3. 3.Lab for Retinal Cell Biology, Department of Ophthalmology, CIHPUniversity of Zurich, University Eye HospitalZurichSwitzerland
  4. 4.Retinal Diagnostics Research Group, Department of Ophthalmology IIUniversity of TübingenGermany

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