ERG Responses and Microarray Analysis of Gene Expression in a Multifactorial Murine Model of Age-Related Retinal Degeneration

  • Goldis Malek
  • Jeffery A. Jamison
  • Brian Mace
  • Patrick Sullivan
  • Catherine Bowes Rickman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 613)

Age-related macular degeneration (AMD) is a late-onset neurodegenerative retinal eye disease that manifests as progressive loss of central vision. It is a common disease caused by the interaction of genetic predisposition and exposure to modifiable risk factors. Risk factors identified to date include but are not limited to: advanced age, environmental factors (e.g. smoking, diet) (Chua et al. 2006; Guymer and Chong 2006; Seddon et al. 2006; Weale 2006) and genetics (e.g. complement factors H & B, LOC387715, and apolipoprotein E [APOE]) (Klaver et al. 1998; Souied et al. 1998; Schmidt et al. 2002; Edwards Iii et al. 2005;Hageman et al. 2005;Haines et al. 2005; Klein et al. 2005; Conley et al. 2006; Gold et al. 2006).We developed a murine model that closely approximates changes seen in human AMD, by combining advanced age, human APOE isoform and a high fat, cholesterol-rich (HF-C) diet, three risk factors associated with the human disease (Malek et al. 2005).


Retinal Pigment Epithelium Outer Nuclear Layer APOE4 Mouse Target Replacement Mouse Photoreceptor Gene Expression 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Goldis Malek
    • 1
  • Jeffery A. Jamison
    • 2
  • Brian Mace
    • 3
  • Patrick Sullivan
    • 3
  • Catherine Bowes Rickman
    • 4
  1. 1.Department of OphthalmologyDuke UniversityUSA
  2. 2.Retina Discovery UnitAlcon Research, Ft. Worth
  3. 3.Department of NeurologyDuke UniversityDurham
  4. 4.Department of Ophthalmology, Department of Cell BiologyDuke UniversityDurham

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