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Loss of Visual and Retinal Function in Light-stressed Mice

  • Drew Everhart
  • Ana Stachowiak
  • Yumiko Umino
  • Robert Barlow
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 613)

Extreme light exposure is an environmental factor that can lead to photoreceptor apoptosis and retinal degeneration (Noell and Albrecht, 1971; Reme et al., 1995). Photoreceptor apoptosis is the final cell death pathway in retinal diseases such agerelated macular degeneration (AMD) and retinitis pigmentosa (RP). Extreme light stress also accelerates underlying retinal disease in many animal models (Wenzel et al., 2005), providing further evidence for light exposure as an independent risk factor for retinal degeneration. For these reasons, the study of light-induced degeneration in mice may provide a valuable model for uncovering the mechanisms of retinal diseases.

Keywords

Light Exposure Visual Function Contrast Sensitivity Retinal Degeneration Retinal Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Drew Everhart
    • 1
  • Ana Stachowiak
    • 2
  • Yumiko Umino
    • 3
  • Robert Barlow
    • 4
  1. 1.Center for Vision Research, Department of OphthalmologyUpstate Medical UniversitySyracuseU.S.A
  2. 2.IInstitute for Sensory ResearchSyracuse University, SyracuseU.S.A
  3. 3.Center for Vision Research, Department of OphthalmologyUpstate Medical UniversitySyracuseU.S.A
  4. 4.Center for Vision Research, Department of OphthalmologyUpstate Medical UniversitySyracuseU.S.A

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