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Development of Viral Vectors with Optimal Transgene Expression for Ocular Gene Therapies

  • Takao Hashimoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 613)

Various efforts have been dedicated to the development of effective strategies to treat ocular diseases. Investigators have demonstrated that gene therapies using viral vectors are one of the promising technologies. For an ideal therapeutic effect, a variety of vector designs have been tested. Especially, selection of a promoter to drive a transgene is important to obtain adequate level of expression. In this brief chapter, reviewed are the promoters for viral vectors for ocular gene therapies.

Keywords

Retinal Pigment Epithelium Retinitis Pigmentosa Trabecular Meshwork Choroidal Neovascularization Retinal Degeneration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Jules Stein Eye InstituteUniversity of California Los AngelesU.S.A

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