Development of Viral Vectors with Optimal Transgene Expression for Ocular Gene Therapies
Various efforts have been dedicated to the development of effective strategies to treat ocular diseases. Investigators have demonstrated that gene therapies using viral vectors are one of the promising technologies. For an ideal therapeutic effect, a variety of vector designs have been tested. Especially, selection of a promoter to drive a transgene is important to obtain adequate level of expression. In this brief chapter, reviewed are the promoters for viral vectors for ocular gene therapies.
KeywordsRetinal Pigment Epithelium Retinitis Pigmentosa Trabecular Meshwork Choroidal Neovascularization Retinal Degeneration
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