Signaling pathways can be defined by an initiation stage and an effector stage. The initiation phase is triggered by ligand binding to its receptor. This biochemical event generates the effector stage with more or less numerous chemical reactions leading to specific cell responses. Signal propagation can be achieved by proteic complex assemblings, protein activation cascades, protein turnovers, and post-translational modifications of proteins, such as phosphorylation/dephosphorylation, glycosylation, ubiquitination, acetylation, which reversibly modify the properties of involved proteic effectors.
KeywordsFocal Adhesion Kinase Adenylyl Cyclase Hippo Pathway Inositol Trisphosphate Myosin Light Chain Phosphatase
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