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Translational Research in Composite Tissue Allotransplantation

  • Linda C. Cendales
  • David E. Kleiner
  • Allan D. Kirk

Patients suffering from severe tissue loss secondary to burns, traumatic injuries, or tumor resections have limited options for reconstruction when autologous tissue for reconstruction is scarce. Composite tissue allotransplantation (CTA) has recently been introduced as a potential clinical treatment for functionally significant tissue loss. CTA has emerged as an amalgamation of advanced microsurgical techniques for limb and flap autotransplantation, and improved immunosuppressive agents to prevent rejection. However, as a developing field, it is yet to have its unique immunological properties established.

Keywords

Acute Rejection Radial Forearm Flap Composite Tissue Brachioradialis Muscle Severe Rejection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2008

Authors and Affiliations

  • Linda C. Cendales
    • 1
  • David E. Kleiner
    • 2
  • Allan D. Kirk
    • 3
  1. 1.Hand and Microsurgery and Composite Tissue Allotransplantation, Orthopedic SectionNIAMS, National Institutes of HealthBethesda
  2. 2.Laboratory of PathologyNational Cancer InstituteBethesda
  3. 3.National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of HealthBethesda

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