The Impact of the Discovery of Cyclosporine on Transplantation of Composite Tissue Allografts

  • Zsolt T. Csapo
  • Bence Forgacs
  • Barry D. Kahan

Over the past 30 years, progress in basic science, immunopharmacology, and clinical practice has engendered exciting improvements in the field of transplantation that have resulted in longer patient and graft survivals and a better quality of life for recipients. Composite tissue transplantation has benefited from developments in organ transplantation: harvest of tissue from deceased donors and improved immunosuppression. The goal of organ transplantation — an efficient yet nontoxic immunosuppressive regimen — is particularly necessary for composite transplants because these grafts are not vital to host survival.


Graft Survival Mycophenolate Mofetil Deceased Donor Allograft Survival Composite Tissue 
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Copyright information

© Springer 2008

Authors and Affiliations

  • Zsolt T. Csapo
    • 1
  • Bence Forgacs
    • 2
  • Barry D. Kahan
    • 3
    • 4
  1. 1.Division of Immunology and Organ TransplantationUniversity of Texas at Houston School of Medicine, University of Texas Health Science Center at HoustonHouston
  2. 2.Division of Immunology and Organ TransplantationUniversity of Texas Health Science CenterHouston
  3. 3.University of Texas at Houston School of MedicineHouston
  4. 4.Division of Immunology and Organ TransplantationUniversity of Texas Health Science Center at HoustonHouston

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