Face Transplantation

  • Maria Siemionow
  • Galip Agaoglu

Thousands of patients with severe facial disfigurements due to burns, trauma, and tumor excisions are seeking surgical treatment to reduce their suffering. Unfortunately, the aesthetic outcome of the currently available conventional reconstructive procedures (e.g., skin grafts, flaps) for facial reconstruction is not satisfactory in long-term follow-up. The best result of facial reconstruction was obtained following replantation of total face and scalp avulsion with adequate hair growth on the scalp and normal animation of the facial expression muscles.


Common Carotid Artery External Jugular Vein Superficial Temporal Artery Facial Skin Facial Reconstruction 
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  1. 1.
    A. Thomas, V. Obed, A. Murarka, et al., Total face and scalp replantation, Plast Reconstr Surg 102, 2085–2087 (1998).PubMedCrossRefGoogle Scholar
  2. 2.
    B. J. Wilhelmi, R. H. Kang, K. Movassaghi, et al., First successful replantation of face and scalp with single-artery repair: model for face and scalp transplantation, Ann Plast Surg 50, 535–540 (2003).PubMedCrossRefGoogle Scholar
  3. 3.
    J. M. Dubernard, E. Owen, G. Herzberg, et al., Human hand allograft: report on first 6 months, Lancet 353, 1315–1320 (1999).PubMedCrossRefGoogle Scholar
  4. 4.
    P. E. M. Butler, A. Clarke, R. E. Aschcroft, Face transplantation: when and for whom? Am J Bioethics 4, 16–17 (2004).CrossRefGoogle Scholar
  5. 5.
    O. P. Wiggins, J. H. Barker, S. Martinez, et al., On the ethics of facial transplantation research, Am J Bioethics 4, 1–12 (2004).CrossRefGoogle Scholar
  6. 6.
    P. J. Morris, J. A. Bradley, L. Doyal, et al., Facial transplantation: a working party report from the Royal College of Surgeons of England, Transplantation 77, 330–338 (2004).PubMedCrossRefGoogle Scholar
  7. 7.
    M. Siemionow, B. Gozel-Ulusal, A. Ulusal, et al., Functional tolerance following face transplantation in the rat, Transplantation 75, 1607–1609 (2003).PubMedCrossRefGoogle Scholar
  8. 8.
    B. G. Ulusal, A. E. Ulusal, S. Ozmen, et al., A new composite facial and scalp transplantation model in rats, Plast Reconstr Surg 112, 1302–1311 (2003).PubMedCrossRefGoogle Scholar
  9. 9.
    S. Unal, G. Agaoglu, M. Siemionow, New surgical approach in facial transplantation extends survival of allograft recipients, Ann Plast Surg 55(3), 297–303 (2005).PubMedCrossRefGoogle Scholar
  10. 10.
    Y. Demir, S. Ozmen, A. Klimczak, Tolerance induction in composite facial allograft transplantation in the rat model, Plast Reconstr Surg 114, 1790–1801 (2004).PubMedCrossRefGoogle Scholar
  11. 11.
    Y. Demir, S. Ozmen, A. Klimczak, et al., Strategies to develop chimerism in vascularized skin allografts across MHC barrier. Microsurgery 25(5), 415–22 (2005).PubMedCrossRefGoogle Scholar
  12. 12.
    H. J. Buncke, W. Y. Hoffman, B. S. Alpert, et al., Microvascular transplant of two free scalp flaps between identical twins, Plast Reconstr Surg 70, 605–609 (1982).PubMedCrossRefGoogle Scholar
  13. 13.
    H. Q. Jiang, Y. Wang, X. B. Hu, Y. S. Li, J. S. Li, Composite tissue allograft transplantation of cephalocervical skin flap and two ears, Plast Reconstr Surg 115(3), 31e–35e; discussion 36e–37e (2005).PubMedCrossRefGoogle Scholar
  14. 14.
    M. Siemionow, G. Agaoglu, Controversies following the report on transplantation of cephalocervical skin flap, Plast Reconstr Surg 118(1), 268–270 (2006).PubMedCrossRefGoogle Scholar
  15. 15.
    M. Siemionow, S. Unal, G. Agaoglu, et al., A cadaver study in preparation for facial allograft transplantation in humans: Part I. What are alternative sources for total facial defect coverage? Plast Reconstr Surg 119(3), 1114–1115 (2006).Google Scholar
  16. 16.
    M. Siemionow, G. Agaoglu, S. Unal, A cadaver study in preparation for facial allograft transplantation in humans: Part II. Mock facial transplantation, Plast Reconstr Surg 117(3), 876–885 (2006).PubMedCrossRefGoogle Scholar
  17. 17.
    A. Caplan, Facing ourselves, Am J Bioethics 4, 18–20 (2004).CrossRefGoogle Scholar
  18. 18.
    M. Siemionow, G. Agaoglu, Allotransplantation of the face: how close are we? Clin Plast Surg 32, 401–409 (2005).PubMedCrossRefGoogle Scholar
  19. 19.
    Working Group-Comité Consultatif National d’Ethique (CCNE): Composite Tissue Allotransplantation of the Face (Full or Partial Facial Transplant) (6 February 2004).
  20. 20.
    G. J. Agich, M. Siemionow, Facing the ethical questions in facial transplantation, Am J Bioethics 4, 25–27 (2004).CrossRefGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Maria Siemionow
    • 1
  • Galip Agaoglu
    • 2
  1. 1.The Cleveland Clinic FoundationCleveland Clinic Lerner College of Medicine of Case Western Reserve UniversityCleveland
  2. 2.Division of Plastic SurgeryThe Cleveland Clinic FoundationCleveland

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