Composite tissue allografts (CTAs) represent the transplantation of several tissue types including integumentary, musculoskeletal, cutaneous, and hematopoietic elements. The rat hindlimb CTA using a parental limb to an F1 hybrid host actually represents a vascularized bone marrow transplant model. The hindlimb CTA provides transplantation of precursor hematolymphoid (bone marrow) and mature (blood and lymph nodes) elements by a surgical approach along with transfer of their syngeneic/supportive microenvironments. Immediate engraftment with and without immune modulation has been previously shown.
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Ramsamooj, R., Hewitt, C.W. (2008). Vascularized Bone Marrow Transplantation: Pathology of Composite Tissue Transplantation-Induced Graft-Versus-Host-Disease. In: Hewitt, C.W., Lee, W.P.A., Gordon, C.R. (eds) Transplantation of Composite Tissue Allografts. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-74682-1_19
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