Vascularized Bone Marrow Transplantation: Pathology of Composite Tissue Transplantation-Induced Graft-Versus-Host-Disease
Composite tissue allografts (CTAs) represent the transplantation of several tissue types including integumentary, musculoskeletal, cutaneous, and hematopoietic elements. The rat hindlimb CTA using a parental limb to an F1 hybrid host actually represents a vascularized bone marrow transplant model. The hindlimb CTA provides transplantation of precursor hematolymphoid (bone marrow) and mature (blood and lymph nodes) elements by a surgical approach along with transfer of their syngeneic/supportive microenvironments. Immediate engraftment with and without immune modulation has been previously shown.
KeywordsAcute GVHD Chronic GVHD Donor Chimerism Mixed Chimerism Composite Tissue
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