Relaxin-Like Ligand-Receptor Systems Are Autocrine/Paracrine Effectors in Tumor Cells and Modulate Cancer Progression and Tissue Invasiveness

  • Thomas Klonisch
  • Joanna Bialek
  • Yvonne Radestock
  • Cuong Hoang-Vu
  • Sabine Hombach-Klonisch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 612)


Relaxin and INSL3 are novel autocrine/paracrine insulin-like hormones in tumor biology. Both effectors can bind to and activate the leucine-rich G-protein coupled receptors LGR7 (relaxin receptor) or LGR8 (relaxin/INSL3 receptor). These relaxin-like ligand-receptor systems modulate cellular functions and activate signaling cascades in a tumor-specific context leading to changes in tumor cell proliferation, altered motility/migration and enhanced production/secretion of potent proteolytic enzymes. Matrix-metalloproteinases (MMP), tissue inhibitors of metalloproteinases (TIMP) and acid hydrolases such as cathepsins can facilitate tissue degradation and represent important proteolytic mediators of relaxin-like actions on tumor cell invasion and metastasis. This review presents recent new findings and emphasises the important functions of the relaxin/INSL3 ligand-receptor system as novel autocrine/paracrine effectors influencing tumor progression and tissue invasiveness.


Thyroid Carcinoma Leydig Cell Leydig Cell Tumor Human Relaxin Human Thyroid Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Thomas Klonisch
    • 1
  • Joanna Bialek
    • 2
  • Yvonne Radestock
    • 2
  • Cuong Hoang-Vu
    • 2
  • Sabine Hombach-Klonisch
    • 1
  1. 1.Department of Human Anatomy and Cell Science, Faculty of MedicineUniversity of ManitobaWinnipegCanada
  2. 2.Universitätsklinik und Poliklinik für Allgemein Viszeral- und GefäßchirurgieMartin-Luther-Universität Halle-WittenbergHalle/SaaleGermany

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