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Tissue Engineering of Small– and Large– Diameter Blood Vessels

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Strategies in Regenerative Medicine

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Authors and Affiliations

  1. Division of Regenerative Medicine (Tissue Engineering and Cell Transplantation), Department of Surgical Research and Clinic for Cardiovascular Surgery, University and University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland

    Dörthe Schmidt

Authors
  1. Dörthe Schmidt
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  2. Simon P. Hoerstrup
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Corresponding author

Correspondence to Dörthe Schmidt .

Editor information

Editors and Affiliations

  1. School of Pharmacy &, Biomolecular Sciences, University of Brighton, Lewes Road, Brighton, BN2 4GJ, United Kingdom

    Matteo Santin

Additional information

Questions/Exercises

  1. 1.

    Which are the two natural grafts used in bypass applications? What are their tissues of origin, how well do they match the vessel to be replaced, and how do they perform in clinics?

  2. 2.

    What are the main polymeric biomaterials used for synthetic graft manufacture and the principal method of engineering? Describe their biocompatibility and clinical performance in the light of their physico-chemical properties.

  3. 3.

    Describe the ideal properties of a vascular graft and compare them with the features of a typical, commercially available device.

  4. 4.

    Critically analyze two main tissue engineering approaches for small-diameter blood vessel regeneration.

  5. 5.

    Which are the main cell types to be used in the assembling of a tissue engineering construct for vessel replacement?

  6. 6.

    Name the main sources of stem cells for tissue engineering of blood vessels and analyze advantages and disadvantages in their use.

  7. 7.

    What are the biomolecular bases of the blood vessel mechanical properties? Can they be reproduced by synthetic grafts and tissue engineering constructs?

  8. 8.

    Give an example of a bioreactor system for tissue engineering of blood vessel. Describe the biomaterial, cell, and environmental conditions used and the rationale underpinning their choice.

  9. 9.

    What are the principal animal models employed for the in vivo assessment of blood vessel grafts and tissue engineering constructs?

  10. 10.

    Provide an overview of the clinical experience for blood vessel tissue engineering and compare it with the performance of traditional grafts and bypasses.

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Schmidt, D., Hoerstrup, S.P. (2009). Tissue Engineering of Small– and Large– Diameter Blood Vessels. In: Santin, M. (eds) Strategies in Regenerative Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-74660-9_7

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