Angiogenesis in Development, Disease, and Regeneration

  • Rakesh K. Jain
  • Dai Fukumura


The cardio-vascular system consists of the heart, arterial networks, capillary plexuses, and venous networks (, Working in parallel with the blood circulation is the lymphatic system that drains interstitial fluid from tissue and returns it back into the venous blood circulation. The circulatory systems arose during evolution to provide transport routes for supplying nutrients, soluble factors and gaseous molecules, and removing waste products and metabolic intermediates from different tissues in the body. These functions are required to maintain homeostasis. When the circulatory system goes awry, it can result in a number of different diseases. For example, when circulation is partially or completely disrupted, or when vessels become structurally or functionally abnormal, the affected tissue rapidly undergoes a number of physiological changes related to the drop in tissue oxygenation (hypoxia). This...


Endothelial Cell Vascular Endothelial Growth Factor Vascular Endothelial Growth Factor Expression Tumor Vessel Vascular Endothelial Growth Factor Signaling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Harvard Medical School and Edwin L. Steele Laboratory for Tumor Biology Department of Radiation Oncology Massachusetts General HospitalBoston

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