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Biomimetic and Bio-responsive Materials in Regenerative Medicine

Intelligent Materials for Healing Living Tissues

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Strategies in Regenerative Medicine

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Author information

Authors and Affiliations

  1. Department of Bioengineering, University of California, , Berkeley

    Jacob F. Pollock

Authors
  1. Jacob F. Pollock
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  2. Kevin E. Healy
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Editor information

Editors and Affiliations

  1. School of Pharmacy &, Biomolecular Sciences, University of Brighton, Lewes Road, Brighton, BN2 4GJ, United Kingdom

    Matteo Santin

Additional information

Questions/Exercises

  1. 1.

    Explain the differences between traditional, early generation biomaterials and modern, biomimetic materials for regenerative medicine. How has knowledge of tissue physiology altered biomaterial design philosophy? What are the differences in host response between these types of materials?

  2. 2.

    Which aspects of natural tissues and ECMs have been mimicked in biomaterials? How do these influence cell function and tissue formation?

  3. 3.

    Describe the mechanisms of biomimetic materials that can be utilized to achieve cell- and tissue-specific response. Explain with examples.

  4. 4.

    Describe the general roles of receptor-ligand dynamics in cell behavior. What are the similarities, differences, and interactions of the receptor-ligand dynamics of growth factors and cell-adhesion ligands? Name at least three roles of enzymes in tissue dynamics.

  5. 5.

    Give examples of tissue dynamic processes. How are the feedback mechanisms between cells and the ECM bidirectional? What is the term for these interactions?

  6. 6.

    What are three fundamental strategies of biomaterials for directed tissue growth? How are these complementary? Give specific examples of their use in advanced biomimetic materials design.

  7. 7.

    Describe several methods can be used to form biomaterials in situ? What are the advantages of in situ biomaterial formation for tissue regeneration?

  8. 8.

    List aspects of cell-adhesion domains which can be controlled in biomimetic materials? How do these aspects influence cell behavior? What methods are used to incorporate cell-adhesion domains?

  9. 9.

    What are the advantages of enzymatic degradability in biomimetic materials? Describe specific ways that this property can be imparted?

  10. 10.

    List at least three methods of incorporating growth factor activity into biomimetic materials. Predict the release profiles of growth factors from these materials.

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West JL, Hubbell JA. (1999) Polymeric biomaterials with degradation sites for proteases involved in cell migration. Macromolecules 32(1):241–244.

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Pollock, J.F., Healy, K.E. (2009). Biomimetic and Bio-responsive Materials in Regenerative Medicine. In: Santin, M. (eds) Strategies in Regenerative Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-74660-9_4

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