Soft Tissues Characteristics and Strategies for Their Replacement and Regeneration

  • Maurizio Ventre
  • Paolo A. Netti
  • Francesco Urciuolo
  • Luigi Ambrosio

Composition-Structure-Properties of Soft Tissues: Introduction

The extracellular matrix (ECM) of connective tissues is usually represented as a composite material, in which insoluble fibers are embedded in an aqueous matrix containing a wide variety of soluble macromolecules. The main characteristic of the ECM is to provide the tissue with specific physiological and biomechanical properties. These macroscopic properties are strictly related to the tissue composition and spatial arrangement of its microconstituents.

The most abundant proteins of the ECM of vertebrate body belong to the family of collagens. In particular, fibril forming collagens have been widely examined due to their property to form high ordered structure. Alongside collagens, elastin and proteoglycans play important mechanical and biological functions.

In collagen rich soft biological tissues exists a correlation between their inner microstructure and their macroscopic mechanical properties. The interest in the...


Anterior Cruciate Ligament Articular Cartilage Collagen Fiber Hyaline Cartilage Collagen Bundle 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Maurizio Ventre
  • Paolo A. Netti
    • 1
  • Francesco Urciuolo
  • Luigi Ambrosio
  1. 1.Interdepartmental Centre on BiomaterialsUniversity of Naples Federico IIItaly

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