Cartilage Development, Physiology, Pathologies, and Regeneration

  • Xibin Wang
  • Lars Rackwitz
  • Ulrich Nöth
  • Rocky S. Tuan


Articular cartilage covers the end of long bones. It provides a smooth surface for joint articulation and confers resilient properties for dynamic loadings. In general, cartilage defects in adult humans fail to heal spontaneously and usually lead to progressive cartilage destruction, which is the major feature of osteoarthritis, a debilitating joint disease prevalent in older population. Thus, repair and regeneration of articular cartilage is of great public interest. Experimental and clinical studies have shown the possibility to transplant chondrocytes into isolated cartilage defects, with or without scaffold material, to restore the articular surface. Mesenchymal stem cells (MSCs) offer a new cell source to develop sufficient quantity of cartilage analogue for the reconstruction of damaged or degenerated articular cartilage. Successful articular cartilage repair and regeneration depends critically on understanding cartilage biology. This chapter will first review...


Articular Cartilage Collagen Type Subchondral Bone Cartilage Defect Cartilage Repair 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Xibin Wang
  • Lars Rackwitz
  • Ulrich Nöth
  • Rocky S. Tuan
    • 1
  1. 1.Department of Health and Human Services, Cartilage Biology and Orthopaedics BranchNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of HealthBethesdaUSA

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