Peripheral Nerve Injury, Repair, and Regeneration

  • Rudolf K. Potucek
  • Stephen W.P. Kemp
  • Naweed I. Syed
  • Rajiv Midha


Injuries to the peripheral nervous system (PNS) present a serious health problem for society, affecting approximately 2.8% of all trauma cases, often resulting in poor recovery of function and subsequent impaired quality of life for the patient (McAllister et al. 1996, Noble et al. 1998, Belkas et al. 2004, Lundborg 2004). For example, approximately 360,000 people in the United States alone suffer from paralytic syndromes of the upper extremity annually, resulting in 8,648,000 and 4,916,000 restricted activity and bed/disability days respectively (Kelsey et al. 1997). Approximately 100,000 patients undergo neurosurgical procedures of the PNS in the United States and Europe annually (Schlosshauer et al. 2006). The majority of patients with PNS injury has both motor and sensory deficits and often suffer from neuropathic pain. In contrast to the central nervous system (CNS), the PNS may exhibit spontaneous regeneration, albeit over shorter distances, with poor recovery of...


Schwann Cell Nerve Regeneration Trophic Factor Peripheral Nerve Injury Nerve Graft 
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  1. Akun T, Najafi K, Bradley RM (1994) A micromachined silicon sieve electrode for nerve regeneration applications. IEEE Trans Biomed Eng 41:305–313CrossRefGoogle Scholar
  2. Al-Majed AA, Neumann CM, Brushart TM, Gordon T (2000) Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration. J Neurosci 20: 2602–2608Google Scholar
  3. Al-Majed, AA, Tam, SL, Gordon T (2004) Electrical stimulation accelerates and enhances expression of regeneration-associated genes in regenerating rat femoral motoneurons. Cell Mol Neurobiol 24:379–402CrossRefGoogle Scholar
  4. Anglin E, Schwartz M, Ng V, Perelman L, Sailor M (2004) Engineering the chemistry and nanostructure of porous silicon fabry-pérot films for loading and release of a steroid. Langmuir 20:11264–11269CrossRefGoogle Scholar
  5. Archibald SJ, Krarup C, Shefner J, Li S-T, Madison RD (1991) A collagen-based nerve guide conduit for peripheral nerve repair: an electrophysiological study of nerve regeneration in rodents and nonhuman primates. J Comp Neurol 306:685–696CrossRefGoogle Scholar
  6. Archibald SJ, Shefner J, Krarup C, Madison RD (1995) Monkey median nerve repaired by nerve graft or collagen nerve guide tube. J Neurosci 15:4109–4123Google Scholar
  7. Baffour R, Achanta K, Kaufman J, Berman J, Garb JL, Rhee S, Friedmann P (1995) Synergistic effect of basic fibroblast growth factor and methylprednisolone on neurologic function after experimental spinal cord injury. J Neurosurg 83:105–110CrossRefGoogle Scholar
  8. Belkas JS, Shoichet MS, Midha R (2004) Peripheral nerve regeneration through guidance tubes. Neurol Res 26:151–160CrossRefGoogle Scholar
  9. Bellamkonda RV (2006) Peripheral nerve regeneration: an opinion on channels, scaffolds and anisotropy. Biomaterials 27:3515–3518Google Scholar
  10. Bergveld P, Wiersma J. et al. (1976) Extracellular potential recordings by means of field effect transistor without gate metal, called OSFET. IEEE Trans Biomed Eng 23: 136–144CrossRefGoogle Scholar
  11. Bertelli JA, Ghizoni MF (2004) Reconstruction of C5 and C6 brachial plexus avulsion injury by multiple nerve transfers: spinal accessory to suprascapular, ulnar fascicles to biceps branch, and triceps long or lateral head branch to axillary nerve. J Hand Surg 29:131–139CrossRefGoogle Scholar
  12. Borgens R, Robinson K, Vanable jr J, McGinnis M (1989) Electric fields in vertebrate repair. Alan R. Liss, Inc., New York.Google Scholar
  13. Borgens R, Blight A, McGinnis M (1990) Functional recovery after spinal cord hemisection in guinea pigs: The effects of applied electric fields. J Compar Neurol 296: 634–653CrossRefGoogle Scholar
  14. Borgens R, Toombs J, Blight A, McGinnis M, Bauer M, Widmer W, Cook jr J (1993) Effects of applied electric fields on clinical cases of complete paraplegia in dogs. Restor Neurol Neurosci 5:305–322Google Scholar
  15. Borgens RB, Bohnert DM (1997) The responses of mammalian spinal axons to an applied dc voltage gradient. Experimental Neurology 145:376–389CrossRefGoogle Scholar
  16. Bregman BS, McAtee M, Dai HD, Kuhn PL (1997) Neurotrophic factors increase axonal growth after spinal cord injury and transplantation in the adult rat. Exp Neurol 148:475–494CrossRefGoogle Scholar
  17. Brushart TM, Hoffman PN, Royall RM, Murinson BB, Witzel C, Gordon T (2002) Electrical stimulation promotes motoneuron regeneration without increasing its speed or conditioning the neuron. J Neurosci 22:6631–6638Google Scholar
  18. Brushart TM, Jari R, Verge V, Rohde C, Gordon T (2005) Electrical stimulation restores the specificity of sensory axon regeneration. Exp Neurol 194:221–229CrossRefGoogle Scholar
  19. Campbell P, et al. (1989) A chronic intracortical electrode array: preliminary results. J Biomed Mater Res 23:245–259Google Scholar
  20. Chalfoun C, Wirth G, Evans G (2006) Tissue engineered nerve constructs: where do we stand? J Cell Molecular Med 10:309–317CrossRefGoogle Scholar
  21. Chaudhry V, Glass JD, Griffin JW (1992) Wallerian degeneration in peripheral nerve disease. Neurologic Clinics 10:613–627Google Scholar
  22. Chen YY, McDonald D, Cheng C, Magnowski B, Durand J, Zochodne DW (2005) Axon and Schwann cell partnership during nerve regrowth. J Neuropathol Exp Neurol 64:613–622Google Scholar
  23. Cheng B, Chen Z (2002) Fabricating autologous tissue to engineer artificial nerve. Microsurgery 22:133–137CrossRefGoogle Scholar
  24. Cho ST, Cromack K, Jara-Almonte J, VerLee DJ (2005) Medicine delivery system. In: US006,953,455), vol. October 11.Google Scholar
  25. Clark P, Britland S, Connolly P (1993) Growth cone guidance and neuron morphology on micropatterned laminin surfaces. Journal of Cell Science 105:203–212Google Scholar
  26. Dahlin LB, Lundborg G (1998) Experimental nerve grafting: towards future solutions of a clinical problem 165–173Google Scholar
  27. Deumens R, Koopmans GC, Honig WMM, Hamers FPT, Maquet V, Jerome R, Steinbusch HWM, Joosten EAJ (2006) Olfactory ensheathing cells, olfactory nerve fibroblasts and biomatrices to promote long-distance axon regrowth and functional recovery in the dorsally hemisected adult rat spinal cord. Experimental Neurology 200:89–8103CrossRefGoogle Scholar
  28. Diao E, Vannuyen T (2000) Techniques for primary nerve repair. Hand Clinics 16:53–66Google Scholar
  29. Fu SY, Gordon T (1997) The cellular and molecular basis of peripheral nerve regeneration. Molecular Neurobiology 14:67–116CrossRefGoogle Scholar
  30. Gage FH, Ray J, Fisher LJ (1995) Isolation, Characterization, and use of Stem Cells from the CNS. Annual Review of Neuroscience 18:159–192CrossRefGoogle Scholar
  31. Gibbels E (1989) Morphometry of unmyelinated nerve fibers. Clinical Neuropathology 8:179–187Google Scholar
  32. Gordon T, Sulaiman O, Boyd JG (2003) Experimental strategies to promote functional recovery after peripheral nerve injuries. Journal of the peripheral nervous system 8:236–250CrossRefGoogle Scholar
  33. Hinkle L, McCaig C, Robinson K (1981) The direction of growth of differentiating neurones and myoblasts from frog embryos in an applied electric field. The Journal of Physiology (London) 313:121–135Google Scholar
  34. Hochberg LR, Serruya MD, Friehs GM, Mukand JA, Saleh M, Caplan AH, Branner A, Chen D, Penn RD, Donoghue JP (2006) Neuronal ensemble control of prosthetic devices by a human with tetraplegia. Nature 442:164–171CrossRefGoogle Scholar
  35. Hou S-Y, Zhang H-Y, Quan D-P, Liu X-L, Zhu J-K (2006) Tissue-engineered peripheral nerve grafting by differentiated bone marrow stromal cells. Neuroscience 140:101–110CrossRefGoogle Scholar
  36. Hou Z, Xu Z (2002) Nerve transfer for treatment of brachial plexus injury: comparison study between the transfer of partial median and ulnar nerves and that of phrenic and spinal accessary nerves. Chinese Journal of Traumatology 5:263–266Google Scholar
  37. Hudson AR, Morris J, Weddell G, Drury A (1972) Peripheral nerve autografts. The Journal of Surgery Research 12:267–274CrossRefGoogle Scholar
  38. Johansson F, Kanje M, Eriksson C, Wallman L (2005) Guidance of neurons on porous patterned silicon: is pore size important? Physica Status Solidi (C) 2:3258–3262CrossRefGoogle Scholar
  39. Kajitani I, Murakawa M, Nishikawa D, Yokoi H, Kajihara N, Iwata M, Keymeulen D, Sakanashi H, Higuchi T (1999) An evolvable hardware chip for prosthetic hand controller. MicroNeuro '99. Proceedings of the Seventh International Conference on Microelectronics for Neural, Fuzzy and Bio-Inspired Systems, 1999 pp. 179–186Google Scholar
  40. Kaul R, Syed N, Fromherz P (2004) Neuron-semiconductor chip with chemical synapse between identified neurons. Physical Review Letters 92: 038102CrossRefGoogle Scholar
  41. Keilhoff G, Goihl A, Stang F, Wolf G, Fansa H (2006a) Peripheral nerve tissue engineering: Autologous Schwann cells vs. transdifferentiated mesechymal stem cells. Tissue Engineering 12:1454–1465Google Scholar
  42. Keilhoff G, Goihl A, Stang F, Wolf G, Fansa H (2006b) Peripheral Nerve Tissue Engineering: Autologous Schwann Cells vs. Transdifferentiated Mesenchymal Stem Cells. Tissue Engineering 12:1451–1465Google Scholar
  43. Kelsey JL, Praemer A, Nelson L, Felberg A, Rice LM (1997) Upper extremity disorders. Frequency, impact, and cost. Churchill Livingstone Inc., New York.Google Scholar
  44. Kline D, Hudson A (1995) Vertebral artery compression. J Neurosurg 83:759Google Scholar
  45. Kovacs, GTA, Storment CW, Rosen JM (1992) Regeneration microelectrode array for peripheral nerve recording and stimulation. IEEE Transactions on Biomedical Engineering. 39:893–902CrossRefGoogle Scholar
  46. Kriesel MS (2002) Fluid delivery device with heat activated energy source. US006 485:462Google Scholar
  47. Kruger GM, Mosher JT, Bixby S, Joseph N, Iwashita T, Morrison SJ (2002) Neural Crest Stem Cells Persist in the Adult Gut but Undergo Changes in Self-Renewal, Neuronal Subtype Potential, and Factor Responsiveness. Neuron 35:657–669CrossRefGoogle Scholar
  48. Lee AC, Yu VM, Lowe JB, Brenner MJ, Hunter DA, Mackinnon SE, Sakiyama-Elbert SE (2003) Controlled release of nerve growth factor enhances sciatic nerve regeneration. Experimental Neurology 295–303Google Scholar
  49. Longo FM, Manthorpe M, Skaper SD, Lundborg G, Varon S (1983a) Neuronotrophic activities accumulate in vivo within silicone nerve regeneration chambers. Brain Research 109–117Google Scholar
  50. Longo FM, Skaper SD, Manthorpe M, Williams LR, Lundborg G (1983b) Temporal changes of neuronotrophic activities accumulating in vivo within nerve regeneration chambers. Experimental Neurology 81:756–769Google Scholar
  51. Longo FM, Hayman EG, Davis GE, Ruoslahti E, Engvall E, Manthorpe M, Varon S (1984) Neurite-promoting factors and extracellular matrix components accumulating in vivo within nerve regneration chambers. Brain Research.Google Scholar
  52. Lundborg G (2004) Nerve injury and repair: regeneration, reconstruction, and cortical remodeling. Elsevier, Philadelphia.Google Scholar
  53. Lundborg G, Danielsen N (1991) Injury, degeneration, and regeneration. Gelberman RH (Ed.), Operative Nerve Repair and Reconstruction. J.P. Lippincott, New York.Google Scholar
  54. Lundborg G, Rosen B, Abrahamson SO, Dahlin L, Danielsen N (1994) Tubular repair of the median nerve in the human forearm. Preliminary findings. The Journal of Hand Surgery (British and European Volume) 19:273–276CrossRefGoogle Scholar
  55. Marshall C, Lu C, Winstead W, Zhang X, Xiao M, Harding G, Klueber K, Roisen F (2006) The therapeutic potential of human olfactory-derived stem cells. Histology and Histopathology 21:633–643Google Scholar
  56. Martini R (1994) Expression and functional roles of neural cell surface molecules and extracellular matrix components during development and regeneration of peripheral nerves. Journal of Neurocytology 23:1–28CrossRefGoogle Scholar
  57. Matsuyama T, Mackay MS, Midha R (2000) Peripheral nerve repair and grafting techniques: a review. Neurol Med Chir (Tokyo) 40:187–199CrossRefGoogle Scholar
  58. McAllister RMR, Gilbert SEA, Calder JS, Smith PJ (1996) The epidemiology and management of upper limb peripheral nerve injuries in modern practice. The Journal of Hand Surgery (British and European Volume) 21B:4–13Google Scholar
  59. McCaig CD, Allan DW, Erskine L, Rajnicek AM, Stewart R (1994) Growing Nerves in an Electric Field. Neuroprotocols 4:134–141CrossRefGoogle Scholar
  60. McCaig CD, Rajnicek AM, Song B, Zhao M (2005) Controlling cell behavior electrically: current views and future potential. Physiological Reviews 85:943–979CrossRefGoogle Scholar
  61. McDonald DS, Zochodne DW (2003) An injectable nerve regeneration chamber for studies of unstable soluble growth factors. J Neurosci Methods 122:171–178CrossRefGoogle Scholar
  62. McKenzie IA, Biernaskie J, Toma JG, Midha R, Miller FD (2006) Skin-Derived Precursors Generate Myelinating Schwann Cells for the Injured and Dysmyelinated Nervous System. J Neurosci 26:6651–6660CrossRefGoogle Scholar
  63. Meek MF, M.D, Coert JH, M.D (2002) Clinical Use of Nerve Conduits in Peripheral-Nerve Repair: Review of the Literature. Journal of Reconstructive Microsurgery 097–110Google Scholar
  64. Merle M, Dellon AL, Campbell JN, Chang PS (1989) Complications from silicon-polymer intubulation of nerves. Microsurgery 10:130–133CrossRefGoogle Scholar
  65. Meyer J-U, Stieglitz T, Ruf HH, Robitzki A, Dabouras V, Wewetzer K, Brinker T (2002) A biohybrid microprobe for implanting into the peripheral nervous system. In: 2nd Annual International IEEE-EMB Special Topic Conference on Microtechnologies in Medicine & Biology) pp. 265–268Google Scholar
  66. Midha R, Munro C, Dalton P, Tator C, Shoichet M (2003) Growth factor enhancement of peripheral nerve regeneration through a novel synthetic hydrogel tube. J Neurosurg 99:555–565CrossRefGoogle Scholar
  67. Miller C, Shanks H, Witt A, Rutkowski G, Mallapragada S (2001) Oriented Schwann cell growth on micropatterned biodegradable polymer substrates. Biomaterials 22:1263–1269CrossRefGoogle Scholar
  68. Nagano M, Sakai A, Takahashi N, Umino M, Yoshioka K, Suzuki H (2003) Decreased expression of glial cell line-derived neurotrophic factor signaling in rat models of neuropathic pain. British Journal of Pharmacology 140:1252–1260CrossRefGoogle Scholar
  69. Nakahara Y, Gage FH, Tuszynski MH (1996) Grafts of fibroblasts genetically modified to secrete NGF, BDNF, NT-3, or basic FGF elicit differential responses in the adult spinal cord. Cell Transplantation 5:191–204CrossRefGoogle Scholar
  70. Narakas AO (1984) Thoughts on neurotization or nerve transfers in irreparable nerve lesions. Clinics in Plastic Surgery 11:153–159Google Scholar
  71. Nath RK, Mackinnon SE, Shenaq SM (1997) New nerve transfers following peripheral nerve injuries. Operative Techniques in Plastic and Reconstructive Surgery 4:2–11CrossRefGoogle Scholar
  72. Nichols CM, Brenner MJ, Fox IK, Tung TH, Hunter DA, Rickman SR, Mackinnon SE (2006) Effects of motor versus sensory nerve grafts on peripheral nerve regeneration. Experimental Neurology 190:347–355CrossRefGoogle Scholar
  73. Nishiura Y, Brandt J, Nilsson A, Kanje M, and Dahlin LB (2004) Addition of cultured Schwann cells to tendon autografts and freeze-thawed muscle grafts improves peripheral nerve regeneration. Tissue Engineering 10:157–164CrossRefGoogle Scholar
  74. Noble J, Munro CA, Prasad VSSV, Midha R (1998) Analysis of upper and lower extremity peripheral nerve injuries in a population of patients with multiple injuries. The Journal of Trauma 45:116–122CrossRefGoogle Scholar
  75. Palti Y (1996) Implantable sensor chip US5,513,636 vol. May 7Google Scholar
  76. Patel N, Poo M (1982) Orientation of neurite growth by extracellular electric fields. J Neurosci 2:483–496Google Scholar
  77. Patel N, Poo M (1984) Perturbation of the direction of neurite growth by pulsed and focal electric fields. J Neurosci 4:2939–2947Google Scholar
  78. Patosky F, Timko BP, Yu G, Fang Y, Greytak AB, Zheng G, Lieber CM (2006) Detection, Stimulation, and Inhibition of Neuronal Signals with High-Density Nanowire Transistor Arrays. Science 313:1100–1104CrossRefGoogle Scholar
  79. Poduslo JF, Curran GL (1996) Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF. Brain Research Molecular Brain Research 36:280–286CrossRefGoogle Scholar
  80. Politis M, Zanakis M, Albala B (1988) Facilitated regeneration in the rat peripheral nervous system using applied electric fields. The Journal of Trauma 28:1375–1381CrossRefGoogle Scholar
  81. Portmann-Lanz CB, Schoeberlein A, Huber A, Sager R, Malek A, Holzgreve W, Surbek DV (2006) Placental mesenchymal stem cells as potential autologous graft for pre- and perinatal neuroregeneration. American Journal of Obstetrics and Gynecology 194:664–673CrossRefGoogle Scholar
  82. Posen JM, Phou HN, Hentz VR (1989) Fascicular tubulization: A comparison of experimental nerve repair techniques in the cat. American Journal of Plastic Surgery 22:467–468CrossRefGoogle Scholar
  83. Rajnicek AM, Robinson KR, McCaig CD (1998) The Direction of Neurite Growth in a Weak DC Electric Field Depends on the Substratum: Contributions of Adhesivity and Net Surface Charge. Developmental Biology 203:412–423CrossRefGoogle Scholar
  84. Richardson PM (1991) Neurotrophic factors in regeneration. Current Opinion in Neurobiology 1:401–406CrossRefGoogle Scholar
  85. Rose TL, Kelliher EM, Robblee LS (1985) Assessment of capacitor electrodes for intracortical stimulation. J Neurosci Methods 12:181–193CrossRefGoogle Scholar
  86. Rutten W, Mouveroux J-M, Buitenweg J, Heida C, Ruardij T, Marani E, Lakke E (2001) Neuroelectronic interfacing with cultured multielectrode arrays toward a cultured probe. Proceedings of the IEEE 89:1013–1029CrossRefGoogle Scholar
  87. Saltzman WM, Olbricht WL (2002) Building drug delivery into tissue engineering. Nature Reviews Drug Discovery 1:177–186CrossRefGoogle Scholar
  88. Santini Jr JT, Cima MJ, Langer RS (1998) Microchip drug delivery devices. US005,797,898), vol. August 25Google Scholar
  89. Santini Jr JT, Cima MJ, Uhland SA (2003a) Thermally-activated microchip chemical delivery devices. US006,527,762 vol. March 4Google Scholar
  90. Santini Jr JT, Cima MJ, Uhland SA (2003b) Thermally-activated microchip chemical delivery devices. In: US006,669,683 vol. December 30Google Scholar
  91. Schlosshauer B, Dreesmann L, Schaller H, Sinis N (2006) Synthetic nerve guide implants in humans: a comprehensive survey. Neurosurgery 59:747–748CrossRefGoogle Scholar
  92. Seaberg RM, Smukler SR, Kieffer TJ, Enikolopov G, Asghar Z, Wheeler MB, Korbutt G, van der Kooy D (2004) Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nature Biotechnology 22:1115–1124CrossRefGoogle Scholar
  93. Seckel B (1990) Enhancement of peripheral nerve regeneration. Muscle & Nerve 13:785–800CrossRefGoogle Scholar
  94. Shanley JF, Parker TL (2006) Therapeutic agent delivery device with controlled therapeutic agent release rates. US007,056,338 vol. June 6Google Scholar
  95. Shapiro S, Borgens R, Pascuzzi R, Roos K, Groff M, Purvines S, Rodgers R, Hagy S, Nelson P (2005) Oscillating field stimulation for complete spinal cord injury in humans: a phase 1 trial. J Neurosurg, Spine 2:3–10CrossRefGoogle Scholar
  96. Sunderland S (1951) A classification of peripheral nerve injuries producing loss of function. Brain 74:491–516CrossRefGoogle Scholar
  97. Sunderland S (1968) Nerve and nerve injuries. Williams & Wilkins, Baltimore.Google Scholar
  98. Thompson DL, Mattes MF, Larson LR, Heruth KT (2003) Single-use therapeutic substance delivery device with infusion rate control. US006,562,000, vol. May 13Google Scholar
  99. Toma JG, Akhavan M, Fernandes KJL, Barnabe-Heider F, Sadikot A, Kaplan DR, Miller FD (2001) Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nature Cell Biology 3:778–784CrossRefGoogle Scholar
  100. Torres MP, Determan AS, Anderson GL, Mallapragada SK, Narasimhan B (2007) Amphiphilic polyanhydrides for protein stabilization and release. Biomaterials 28:108–116CrossRefGoogle Scholar
  101. Trumble TE, McCallister WV (2000) Repair of peripheral nerve defects in the upper extremity. Hand Clinics 16:37–52Google Scholar
  102. Tuttle H (1913) Exposure of the brachial plexus with nerve transplantation. The Journal of the American Medical Association 61:15–17CrossRefGoogle Scholar
  103. Uhland SA (2006) Implantable drug delivery device. US007,052,488, vol. May 30Google Scholar
  104. Wallman L, Levinsson A, Schouenborg J, Holmberg H, Danielsen N, Laurell T (1999) Perforated silicon nerve chips with doped registration electrodes: in vitro performance and in vivo operation. IEEE Transactions on Biomedical Engineering 46:1065–1073CrossRefGoogle Scholar
  105. Weber RA, Breidenbach WC, Brown RE, Jabaley ME, Mass DP (2000) A randomized prospective study of polyglycolic acid conduits for digital nerve reconstruction in humans. Plastic and Reconstructive Surgery 106:1036–1045CrossRefGoogle Scholar
  106. Xu XM, Guenard V, Kleitman N, Aebischer P, Bunge MB (1995) A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord. Experimental Neurology 134:261–272CrossRefGoogle Scholar
  107. Zhao Q, Drott J, Laurell T, Wallman L, Lindstrom K, Bjursten LM, Lundborg G, Montelius L, Danielsen N (1997) Rat sciatic nerve regeneration through a micromachined silicon chip. Biomaterials 18:75–80CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Rudolf K. Potucek
  • Stephen W.P. Kemp
  • Naweed I. Syed
    • 1
  • Rajiv Midha
  1. 1.Hotchkiss Brain Institute, Faculty of MedicineUniversity of CalgaryCalgaryCanada

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