Advertisement

Identifying Novel Target Genes in Psychotic Disorder Network Association Analyses

  • Francine M. Benes
  • Benjamin Lim
  • David Matzilevich
  • John Walsh

Many believe that unique genes for schizophrenia (SZ) and bipolar disorder (BD) are associated with the susceptibility for the respective illnesses. To explore this idea, gene expression profiling (GEP) studies of “whole” hippocampus (HIPP) have been performed on a cohort consisting of SZs, BDs and normal controls and the data have been interrogated using a combination of a global functional analysis of biopathways/clusters and network association analysis. Overall, it appears that BDs may show a down-regulation of genes associated with growth pathways and their receptors. Such changes may mitigate against cell survival and potentially even facilitate apoptotic injury in subjects with BD.

Keywords

Bipolar Disorder Ingenuity Pathway Analysis Focus Gene Bipolar Disorder Group Epidermal Growth Factor Receptor Endocytosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Francine M. Benes
    • 1
  • Benjamin Lim
    • 1
  • David Matzilevich
    • 1
  • John Walsh
    • 1
  1. 1.Program in Structural and Molecular NeuroscienceMcLean HospitalBelmontUSA

Personalised recommendations